PEGylated single-walled carbon nanotubes as co-adjuvants enhance expression of maturation markers in monocyte-derived dendritic cells

This study investigated the application of phospholipid-PEGylated single-walled carbon nanotubes (PL-PEG-SWCNTs) as a safe co-adjuvant for the commercial recombinant hepatitis B virus vaccine to enhance induction of monocyte-derived dendritic cells (MDDCs) differentiation and activation as an immune...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2021-02, Vol.16 (3), p.171-188
Main Authors: Hadidi, Naghmeh, Sharifnia, Zarin, Eteghadi, Atefeh, Shokrgozar, Mohammad Ali, Mossafa, Nariman
Format: Article
Language:English
Subjects:
alum
hepatitis B virus vaccine
monocyte-derived dendritic cells
single-walled carbon nanotubes
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Summary:This study investigated the application of phospholipid-PEGylated single-walled carbon nanotubes (PL-PEG-SWCNTs) as a safe co-adjuvant for the commercial recombinant hepatitis B virus vaccine to enhance induction of monocyte-derived dendritic cells (MDDCs) differentiation and activation as an immune response initiator cell to prompt a long-term immune response after a single dose injection. Immature MDDCs were exposed to PL-PEG-SWCNTs alone and in combination with hepatitis B vaccine. Study results confirm the enhanced expression of maturation markers in human immature MDDCs after PL-PEG-SWCNT exposure. The results suggest that PL-PEG-SWCNT is an efficient co-adjuvant for the commercial recombinant hepatitis B virus vaccine to enhance dendritic cell response stimulation .
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0339