Atlas-based segmentation of cochlear microstructures in cone beam CT

• Published in: International journal for computer assisted radiology and surgery 2021-03, Vol.16 (3), p.363-373
• Main Authors: Powell, Kimerly A., Wiet, Gregory J., Hittle, Brad, Oswald, Grace I., Keith, Jason P., Stredney, Don, Andersen, Steven Arild Wuyts
• Format: Article
• Language: English
• Subjects: Centroids; Computed tomography; Computer Imaging; Computer Science; Datasets; Health Informatics; Image segmentation; Imaging; Mean; Medical imaging; Medicine; Medicine & Public Health; Metric space; Original Article; Pattern Recognition and Graphics; Radiology; Slicing; Software; Surgery; Vision
• ISSN: 1861-6410; 1861-6429
• DOI: 10.1007/s11548-020-02304-x

Purpose To develop an automated segmentation approach for cochlear microstructures [scala tympani (ST), scala vestibuli (SV), modiolus (Mod), mid-modiolus (Mid-Mod), and round window membrane (RW)] in clinical cone beam computed tomography (CBCT) images of the temporal bone for use in surgical simulation software and for preoperative surgical evaluation. Methods This approach was developed using the publicly available OpenEar (OE) Library that includes temporal bone specimens with spatially registered CBCT and 3D micro-slicing images. Five of these datasets were spatially aligned to our internal OSU atlas. An atlas of cochlear microstructures was created from one of the OE datasets. An affine registration of this atlas to the remaining OE CBCT images was used for automatically segmenting the cochlear microstructures. Quantitative metrics and visual review were used for validating the automatic segmentations. Results The average DICE metrics were 0.77 and 0.74 for the ST and SV, respectively. The average Hausdorff distance (AVG HD) was 0.11 mm and 0.12 mm for both scalae. The mean distance between the centroids for the round window was 0.32 mm, and the mean AVG HD was 0.09 mm. The mean distance and angular rotation between the mid-modiolar axes were 0.11 mm and 9.8 degrees, respectively. Visually, the segmented structures were accurate and similar to that manually traced by an expert observer. Conclusions An atlas-based approach using 3D micro-slicing data and affine spatial registration in the cochlear region was successful in segmenting cochlear microstructures of temporal bone anatomy for use in simulation software and potentially for pre-surgical planning and rehearsal.