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Iron-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds

An iron-catalyzed α,β-dehydrogenation of carbonyl compounds was developed. A broad spectrum of carbonyls or analogues, such as aldehyde, ketone, lactone, lactam, amine, and alcohol, could be converted to their α,β-unsaturated counterparts in a simple one-step reaction with high yields.

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Bibliographic Details
Published in:Organic letters 2021-03, Vol.23 (5), p.1611-1615
Main Authors: Zhang, Xiao-Wei, Jiang, Guo-Qing, Lei, Shu-Hui, Shan, Xiang-Huan, Qu, Jian-Ping, Kang, Yan-Biao
Format: Article
Language:English
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Summary:An iron-catalyzed α,β-dehydrogenation of carbonyl compounds was developed. A broad spectrum of carbonyls or analogues, such as aldehyde, ketone, lactone, lactam, amine, and alcohol, could be converted to their α,β-unsaturated counterparts in a simple one-step reaction with high yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00043