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GDF‐15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF‐15) belongs t...
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| Published in: | Journal of cellular physiology 2021-08, Vol.236 (8), p.5564-5581 |
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| container_title | Journal of cellular physiology |
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| creator | Hasanpour Segherlou, Zahra Nouri‐Vaskeh, Masoud Noroozi Guilandehi, Sama Baghbanzadeh, Amir Zand, Ramin Baradaran, Behzad Zarei, Mohammad |
| description | Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF‐15) belongs to transforming growth factor‐β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF‐15 to develop and progress cancer is complicated and remains unclear. GDF‐15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF‐15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.
Growth differentiation factor 15 (GDF‐15) possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 may connect to the evolution of glioblastoma multiform. The antitumorigenic and protumorigenic impacts of GDF‐15 on tumor growth are linked to the cancer type and stage. |
| doi_str_mv | 10.1002/jcp.30289 |
| format | article |
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Growth differentiation factor 15 (GDF‐15) possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 may connect to the evolution of glioblastoma multiform. The antitumorigenic and protumorigenic impacts of GDF‐15 on tumor growth are linked to the cancer type and stage.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30289</identifier><identifier>PMID: 33580506</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adipose tissue ; Biological activity ; Bone growth ; Brain cancer ; Brain tumors ; Cancer ; Drug resistance ; GBM ; GDF‐15 ; Glioblastoma ; glioblastoma multiform ; growth differentiation factor 15 ; Growth factors ; Metastases ; Pathogenesis ; Transforming growth factor-b ; Tumor suppressor genes ; Tumors</subject><ispartof>Journal of cellular physiology, 2021-08, Vol.236 (8), p.5564-5581</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-bd9561fe4129fc58e97cff1e99e6b084bccc1ad9fd04f6b92ef3233a115155a13</citedby><cites>FETCH-LOGICAL-c3539-bd9561fe4129fc58e97cff1e99e6b084bccc1ad9fd04f6b92ef3233a115155a13</cites><orcidid>0000-0002-8642-6795 ; 0000-0002-6656-0292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33580506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasanpour Segherlou, Zahra</creatorcontrib><creatorcontrib>Nouri‐Vaskeh, Masoud</creatorcontrib><creatorcontrib>Noroozi Guilandehi, Sama</creatorcontrib><creatorcontrib>Baghbanzadeh, Amir</creatorcontrib><creatorcontrib>Zand, Ramin</creatorcontrib><creatorcontrib>Baradaran, Behzad</creatorcontrib><creatorcontrib>Zarei, Mohammad</creatorcontrib><title>GDF‐15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF‐15) belongs to transforming growth factor‐β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF‐15 to develop and progress cancer is complicated and remains unclear. GDF‐15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF‐15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.
Growth differentiation factor 15 (GDF‐15) possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 may connect to the evolution of glioblastoma multiform. The antitumorigenic and protumorigenic impacts of GDF‐15 on tumor growth are linked to the cancer type and stage.</description><subject>Adipose tissue</subject><subject>Biological activity</subject><subject>Bone growth</subject><subject>Brain cancer</subject><subject>Brain tumors</subject><subject>Cancer</subject><subject>Drug resistance</subject><subject>GBM</subject><subject>GDF‐15</subject><subject>Glioblastoma</subject><subject>glioblastoma multiform</subject><subject>growth differentiation factor 15</subject><subject>Growth factors</subject><subject>Metastases</subject><subject>Pathogenesis</subject><subject>Transforming growth factor-b</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10E9LwzAYBvAgipvTg19ACl4U7JY0TZt4k81NZaAHPXgKaZrMjP6ZSYvs5kfwM_pJjHbuIHhJwpsfDy8PAMcIDhGE0WgpV0MMI8p2QB9BloZxQqJd0Pd_KGQkRj1w4NwSQsgYxvughzGhkMCkD55nk-nn-wcil8HEiEVVu8bIi2Bl6-1bVHnQvCgrVqr1g8CZRWW0kaKSKjBVsChMnRXCNXUpgrItGqNrW6pDsKdF4dTR5h6Ap-n14_gmnN_PbsdX81BiglmY5YwkSKsYRUxLQhVLpdZIMaaSDNI4k1IikTOdw1gnGYuUxhHGAiGCCBEID8BZl-t3fm2Va3hpnFRFISpVt45HMWUR8Wfq6ekfuqxbW_ntuBcppQklzKvzTklbO2eV5itrSmHXHEH-3Tf3ffOfvr092SS2Wanyrfwt2INRB95Modb_J_G78UMX-QVv44oh</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Hasanpour Segherlou, Zahra</creator><creator>Nouri‐Vaskeh, Masoud</creator><creator>Noroozi Guilandehi, Sama</creator><creator>Baghbanzadeh, Amir</creator><creator>Zand, Ramin</creator><creator>Baradaran, Behzad</creator><creator>Zarei, Mohammad</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8642-6795</orcidid><orcidid>https://orcid.org/0000-0002-6656-0292</orcidid></search><sort><creationdate>202108</creationdate><title>GDF‐15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme</title><author>Hasanpour Segherlou, Zahra ; 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Growth differentiation factor 15 (GDF‐15) possesses tumor suppressor properties, as well as an oncogenic effect. GDF‐15 may connect to the evolution of glioblastoma multiform. The antitumorigenic and protumorigenic impacts of GDF‐15 on tumor growth are linked to the cancer type and stage.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33580506</pmid><doi>10.1002/jcp.30289</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-8642-6795</orcidid><orcidid>https://orcid.org/0000-0002-6656-0292</orcidid></addata></record> |
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| subjects | Adipose tissue Biological activity Bone growth Brain cancer Brain tumors Cancer Drug resistance GBM GDF‐15 Glioblastoma glioblastoma multiform growth differentiation factor 15 Growth factors Metastases Pathogenesis Transforming growth factor-b Tumor suppressor genes Tumors |
| title | GDF‐15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme |
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