Cathelicidin ΔPb-CATH4 derived from Python bivittatus accelerates the healing of Staphylococcus aureus-infected wounds in mice

The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus -infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in th...

Full description

Saved in:
Bibliographic Details
Published in:Amino acids 2021-02, Vol.53 (2), p.313-317
Main Authors: Nagasundarapandian, Soundrarajan, Cho, Hye-sun, Prathap, Somasundaram, Kang, Mingue, Choi, Munjeong, Lee, Yunjung, Jeon, Hyoim, Song, Hyuk, Kim, Jin-Hoi, Park, Chankyu
Format: Article
Language:English
Subjects:
Analytical Chemistry
Antibiotics
Antimicrobial agents
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Cell migration
Cytokines
Immune system
Immunomodulation
Inflammation
Life Sciences
Multidrug resistance
Neurobiology
Proteomics
Python bivittatus
Short Communication
Staphylococcus aureus
Trypsin
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus -infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, ΔPb-CATH4 can promote wound healing by controlling infections including those caused by multidrug-resistant bacteria via its immunomodulatory effects.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-021-02948-2