The diagnostic value of conventional radiography and musculoskeletal ultrasonography in calcium pyrophosphate deposition disease: a systematic literature review and meta-analysis

To examine and compare the accuracy of conventional radiography (CR) and musculoskeletal ultrasonography (US) in the diagnosis of calcium pyrophosphate (CPP) crystals deposition disease (CPPD). A systematic search of electronic databases (PubMed, Embase, and Cochrane), conference abstracts and refer...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2021-05, Vol.29 (5), p.619-632
Main Authors: Cipolletta, E., Filippou, G., Scirè, C.A., Di Matteo, A., Di Battista, J., Salaffi, F., Grassi, W., Filippucci, E.
Format: Article
Language:English
Subjects:
Calcium pyrophosphate deposition disease
Conventional radiography
Crystal arthropathy
Diagnostic accuracy
Ultrasonography
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Summary:To examine and compare the accuracy of conventional radiography (CR) and musculoskeletal ultrasonography (US) in the diagnosis of calcium pyrophosphate (CPP) crystals deposition disease (CPPD). A systematic search of electronic databases (PubMed, Embase, and Cochrane), conference abstracts and reference lists was undertaken. Studies which evaluated the accuracy of CR and/or US in the diagnosis of CPPD, using synovial fluid analysis (SFA), histology or classification criteria as reference tests were included. Subgroup analyses by anatomic site and by reference test were performed. Twenty-six studies were included. Using SFA/histology as reference test, CR and US showed an excellent (CR AUC = 0.889, 95%CI = 0.811–0.967) and an outstanding (US AUC = 0.954, 95%CI = 0.907–1.0) diagnostic accuracy (p 
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2021.01.007