Diagnostic value of combining tumor and inflammatory biomarkers in detecting common cancers in Korea

•Multiple biomarkers are a valid strategy for diagnosing six common cancers in Korea.•The AUC of the models in the test set showed very high accuracy.•The sensitivity of the models for early stage cancer (stage I) was very high. The ultimate goal of cancer screening is to diagnose invasive cancers e...

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Bibliographic Details
Published in:Clinica chimica acta 2021-05, Vol.516, p.169-178
Main Authors: Kim, Young Sun, Kang, Kyung Nam, Shin, Yong Sung, Lee, Ji Eun, Jang, Ji Young, Kim, Chul Woo
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Blood Proteins
Cancer screening
Case-Control Studies
Common cancers
Humans
Inflammatory biomarker
Male
Multiple protein biomarkers
Prostatic Neoplasms
Republic of Korea
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Summary:•Multiple biomarkers are a valid strategy for diagnosing six common cancers in Korea.•The AUC of the models in the test set showed very high accuracy.•The sensitivity of the models for early stage cancer (stage I) was very high. The ultimate goal of cancer screening is to diagnose invasive cancers early, while they are still curable. We aimed to validate the diagnostic value of blood-derived protein biomarkers that we developed for six common cancer in Korea. We have discovered 12 protein biomarkers that are useful in differentiating cancer patients from healthy controls using two-dimensional gel electrophoresis (2-DE), surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS), and literature review. Cancer patients (stomach, colon, liver, lung, breast, and prostate) and control subjects were collected and tested data sets were used to generate predictive models that identify risk scores for each cancer. The validation study was done in serum samples of an independent patient cohort Receiver operating characteristic (ROC) analyses were conducted to evaluate the diagnostic performance of the biomarkercombinations. The AUCs of the model in the test set were 0.971, 0.960, 0.969, 0.942, 0.834, and 0.985 for stomach, colon, liver, lung, breast, and prostate cancer, respectively. Combining multiple tumor and systemic inflammatory biomarkers proved to be a valid strategy in the diagnosis of six common cancers in Korea. Further validation of appropriate screening populations through large-scale clinical trials are warranted.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2021.02.002