Improvement in Liver Stiffness in Pediatric Patients with Hepatitis C Virus after Treatment with Direct Acting Antivirals

To assess the degree of liver stiffness using transient elastography in Egyptian children infected with hepatitis C virus (HCV) at baseline and 1 year after achievement of sustained virologic response (SVR) with direct acting antivirals. This prospective study included children infected with HCV who...

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Published in:The Journal of pediatrics 2021-06, Vol.233, p.126-131
Main Authors: Mogahed, Engy A., El-Karaksy, Hanaa, Abdullatif, Hala, Yasin, Noha A., Nagy, Ahmed, Alem, Shereen Abdel, Eldeen, Hadeel Gamal, El-Raziky, Mona S.
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children
DDAs
fibroscan
fibrosis
hepatitis C
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container_title The Journal of pediatrics
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creator Mogahed, Engy A.
El-Karaksy, Hanaa
Abdullatif, Hala
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Nagy, Ahmed
Alem, Shereen Abdel
Eldeen, Hadeel Gamal
El-Raziky, Mona S.
description To assess the degree of liver stiffness using transient elastography in Egyptian children infected with hepatitis C virus (HCV) at baseline and 1 year after achievement of sustained virologic response (SVR) with direct acting antivirals. This prospective study included children infected with HCV who received treatment with sofosbuvir/ledipasvir and achieved SVR. At baseline and 1 year after achievement of SVR, the extent of hepatic fibrosis was assessed by transient elastography using FibroScan to measure liver stiffness, in addition to noninvasive markers including aspartate aminotransferase/platelet ratio index (APRI) and fibrosis-4 (FIB-4) index. The study included 23 cases that had variable degrees of fibrosis at baseline; their ages ranged between 10 and 18 years. At baseline, 13 patients had F1; 3 patients had F1-F2; 1 patient had F2; 3 patients had F3; 2 had F3-F4; and 2 patients with F4. One year after achievement of SVR, there was a statistically significant improvement in liver stiffness, APRI, and FIB-4 index (P = .03,
doi_str_mv 10.1016/j.jpeds.2021.02.012
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subjects children
DDAs
fibroscan
fibrosis
hepatitis C
title Improvement in Liver Stiffness in Pediatric Patients with Hepatitis C Virus after Treatment with Direct Acting Antivirals
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