Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not su...

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Bibliographic Details
Published in:Calcified tissue international 2021-04, Vol.108 (4), p.496-511
Main Authors: Jørgensen, Hanne Skou, David, Karel, Salam, Syazrah, Evenepoel, Pieter
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Bone strength
Cell Biology
Endocrinology
Kidney diseases
Kidney transplants
Life Sciences
Orthopedics
Osteoporosis
Review
Risk factors
Trauma
Uremia
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Summary:Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-020-00786-0