Interplay of immune components and their association with recurrent pregnancy loss

Maintenance and progression of pregnancy is an intricate process governed by a variety of developmental cues. Recurrent pregnancy loss (RPL) is a complication experienced by expecting mothers that is defined as three or more consecutive pregnancy losses. This review focuses on the dysfunctions of th...

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Bibliographic Details
Published in:Human immunology 2021-03, Vol.82 (3), p.162-169
Main Authors: Tasadduq, Raazia, Ajmal, Laiba, Batool, Farhat, Zafar, Tehniyat, Babar, Aleena, Riasat, Amna, Shakoori, Abdul-Rauf
Format: Article
Language:English
Subjects:
Abortion, Habitual - immunology
Animals
Antibodies
Antibodies - metabolism
Autoantigens - immunology
Female
Humans
Immune System
Immune System - physiology
Immunity - physiology
Isoantigens - immunology
Miscarriage
Pregnancy - immunology
Recurrent Pregnancy Loss
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Summary:Maintenance and progression of pregnancy is an intricate process governed by a variety of developmental cues. Recurrent pregnancy loss (RPL) is a complication experienced by expecting mothers that is defined as three or more consecutive pregnancy losses. This review focuses on the dysfunctions of the immune system as one of the key contributors towards RPL. The current data suggests that the alloimmune and autoimmune factors contribute to the loss of fetus. Such causes despite being recognized as a definitive reason for recurrent pregnancy loss, are still under extensive investigation with new parameters being discovered and scrutinized for their association with RPLs. More in-depth and high throughput studies are required for devising better diagnostic tools and management strategies for the affected female so that they can carry their pregnancy to term.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2021.01.013