Longitudinal symptom network structure in first-episode psychosis: a possible marker for remission

Network approach has been applied to a wide variety of psychiatric disorders. The aim of the present study was to identify network structures of remitters and non-remitters in patients with first-episode psychosis (FEP) at baseline and the 6-month follow-up. Participants ( = 252) from the Korean Ear...

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Published in:Psychological medicine 2022-10, Vol.52 (14), p.3193-3201
Main Authors: Piao, Yan Hong, Yun, Je-Yeon, Nguyen, Thong Ba, Kim, Woo-Sung, Sui, Jing, Kang, Nam-In, Lee, Keon-Hak, Ryu, Seunghyong, Kim, Sung-Wan, Lee, Bong Ju, Kim, Jung Jin, Yu, Je-Chun, Lee, Kyu Young, Won, Seung-Hee, Lee, Seung-Hwan, Kim, Seung-Hyun, Kang, Shi Hyun, Kim, Euitae, Chung, Young Chul
Format: Article
Language:English
Subjects:
Algorithms
Cognitive ability
Humans
Mental depression
Mental disorders
Original Article
Psychiatric Status Rating Scales
Psychopathology
Psychosis
Psychotic Disorders - psychology
Remission
Remission (Medicine)
Rumination
Schizophrenia
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Summary:Network approach has been applied to a wide variety of psychiatric disorders. The aim of the present study was to identify network structures of remitters and non-remitters in patients with first-episode psychosis (FEP) at baseline and the 6-month follow-up. Participants ( = 252) from the Korean Early Psychosis Study (KEPS) were enrolled. They were classified as remitters or non-remitters using Andreasen's criteria. We estimated network structure with 10 symptoms (three symptoms from the Positive and Negative Syndrome Scale, one depressive symptom, and six symptoms related to schema and rumination) as nodes using a Gaussian graphical model. Global and local network metrics were compared within and between the networks over time. Global network metrics did not differ between the remitters and non-remitters at baseline or 6 months. However, the network structure and nodal strengths associated with positive-self and positive-others scores changed significantly in the remitters over time. Unique central symptoms for remitters and non-remitters were cognitive brooding and negative-self, respectively. The correlation stability coefficients for nodal strength were within the acceptable range. Our findings indicate that network structure and some nodal strengths were more flexible in remitters. Negative-self could be an important target for therapeutic intervention.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291720005280