Multifunction in One Molecule: Mitochondrial Imaging and Photothermal & Photodynamic Cytotoxicity of Fast-Response Near-Infrared Fluorescent Probes with Aggregation-Induced Emission Characteristics

• Published in: ACS applied materials & interfaces 2021-02, Vol.13 (7), p.7945-7954
• Main Authors: Zhang, Lu, Wang, Jiang-Lin, Ba, Xiao-Xu, Hua, Si-Yu, Jiang, Peng, Jiang, Feng-Lei, Liu, Yi
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and Medical Applications of Materials and Interfaces; Cell Proliferation - drug effects; Cell Survival - drug effects; Drug Screening Assays, Antitumor; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacology; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria - drug effects; Neoplasms, Experimental - diagnostic imaging; Neoplasms, Experimental - drug therapy; Optical Imaging; Particle Size; PC-3 Cells; Photochemotherapy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - drug therapy; Surface Properties; Tumor Cells, Cultured
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.0c20283

HJS and DHJS, two near-infrared emissive and mitochondria-targeted therapy probes, have been designed. They exhibited photothermal & photodynamic cytotoxicity and aggregation-induced emission (AIE) characteristics. Interestingly, we could receive fluorescence immediately after adding the probes without washing in 1 min. They could quickly enter cancer cells and selectively localized to the mitochondria firstly. When the concentration of probes was low (