Aligned electrospun nerve conduits with electrical activity as a strategy for peripheral nerve regeneration

Peripheral nerve injuries affect the quality of life of people worldwide. Despite advances in materials and processing in recent decades, nerve repair remains a challenge. The autograft is considered the most effective nerve repair in cases of serious injuries in which direct suture is not applied....

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Bibliographic Details
Published in:Artificial organs 2021-08, Vol.45 (8), p.813-818
Main Authors: Castro, Vanessa Oliveira, Merlini, Claudia
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
conductive additive
conduit
Electrical raceways
Electricity
Electrospinning
Guided Tissue Regeneration - methods
Humans
Injuries
Nanotechnology
Nerve Regeneration - physiology
Nerve Transfer - methods
Peripheral Nerve Injuries - surgery
peripheral nerve regeneration
Peripheral nerves
Quality of life
Recovery of Function
Regeneration
Repair
Tissue Scaffolds
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Summary:Peripheral nerve injuries affect the quality of life of people worldwide. Despite advances in materials and processing in recent decades, nerve repair remains a challenge. The autograft is considered the most effective nerve repair in cases of serious injuries in which direct suture is not applied. However, the autograft causes the loss of functionality of the donor site, and additionally, there is a limited availability of donor nerves. Nerve conduits emerge as an alternative to the autograft and nowadays some conduits are available for clinical use. Nevertheless, they still need to be optimized for better functional nerve response. This review proposes to analyze the use of aligned electrospun nerve conduits with electrical activity as a strategy to enhance a satisfactory nerve regeneration and functional recovery. Nerve conduits fabricated by aligned electrospun fibers with conductive additives have been shown as an effective strategy to stimulate neurites sprouting and enhance peripheral nerve functional recovery.
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13942