Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis

Background Gastroesophageal reflux disease (GERD) is a commonly diagnosed gastrointestinal disorder, with a substantial impact on the quality of life. The underlying pathophysiology of GERD is multifactorial and incompletely understood. Abnormal gastric electrical activity, measured using electrogas...

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Bibliographic Details
Published in:Esophagus : official journal of the Japan Esophageal Society 2021-07, Vol.18 (3), p.425-435
Main Authors: Bhat, Sameer, Varghese, Chris, Carson, Daniel A., Hayes, Tommy C. L., Gharibans, Armen A., Andrews, Christopher N., O’Grady, Gregory
Format: Article
Language:English
Subjects:
Adult
Diagnostic tests
Electromyography
Esophagus
Etiology
Gastroenterology
Gastroesophageal reflux
Gastroesophageal Reflux - complications
Humans
Medicine
Medicine & Public Health
Meta-analysis
Pathophysiology
Postprandial Period
Quality of Life
Review Article
Stomach
Surgical Oncology
Systematic review
Thoracic Surgery
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Summary:Background Gastroesophageal reflux disease (GERD) is a commonly diagnosed gastrointestinal disorder, with a substantial impact on the quality of life. The underlying pathophysiology of GERD is multifactorial and incompletely understood. Abnormal gastric electrical activity, measured using electrogastrography (EGG), may contribute. This study aimed to systematically review and meta-analyse the existing literature in which EGG was used in patients with GERD. Methods Databases were systematically searched for studies using EGG in adults with GERD. The primary outcome was the percentage of recording time in the normogastric frequency range. Secondary outcomes were dominant frequency, dominant power, power ratio and prevalence of any EGG abnormality. Results In total, 591 participants (427 patients with GERD; 164 healthy controls) from 13 studies were included. GERD patients spent 17.3% (SMD − 1.18, 95%CI: − 1.84, − 0.52) and 18.7% (SMD − 1.11, 95%CI: − 1.55, − 0.68) less of the preprandial and postprandial recording time in normogastric frequency ranges, respectively, compared to healthy controls. The dominant frequency, dominant power and power ratio were not significantly different to healthy controls in the preprandial and postprandial periods. The pooled prevalence of any EGG abnormality was significantly greater in patients with GERD than in healthy controls [46% (95%CI: 39–64%) vs. 10% (95%CI: 4–23%); p  
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-021-00820-6