Disruptions in oral and nasal microbiota in biomass and tobacco smoke associated chronic obstructive pulmonary disease

Chronic exposures to tobacco and biomass smoke are the most prevalent risk factors for COPD development. Although microbial diversity in tobacco smoke-associated COPD (TSCOPD) has been investigated, microbiota in biomass smoke-associated COPD (BMSCOPD) is still unexplored. We aimed to compare the na...

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Bibliographic Details
Published in:Archives of microbiology 2021-07, Vol.203 (5), p.2087-2099
Main Authors: Agarwal, Dhiraj M., Dhotre, Dhiraj P., Kumbhare, Shreyas V., Gaike, Akshay H., Brashier, Bill B., Shouche, Yogesh S., Juvekar, Sanjay K., Salvi, Sundeep S.
Format: Article
Language:English
Subjects:
Biochemistry
Biomass
Biomedical and Life Sciences
Biotechnology
Cell Biology
Chronic obstructive pulmonary disease
Dysbacteriosis
Ecology
Etiology
Life Sciences
Lung diseases
Microbial Ecology
Microbiology
Microbiota
Microorganisms
Obstructive lung disease
Original Paper
Risk analysis
Risk factors
Rural populations
Smoke
Tobacco
Tobacco smoke
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Summary:Chronic exposures to tobacco and biomass smoke are the most prevalent risk factors for COPD development. Although microbial diversity in tobacco smoke-associated COPD (TSCOPD) has been investigated, microbiota in biomass smoke-associated COPD (BMSCOPD) is still unexplored. We aimed to compare the nasal and oral microbiota between healthy, TSCOPD, and BMSCOPD subjects from a rural population in India. Nasal swabs and oral washings were collected from healthy ( n  = 10), TSCOPD ( n  = 11), and BMSCOPD ( n  = 10) subjects. The downstream analysis was performed using QIIME pipeline (v1.9). In nasal and oral microbiota no overall differences were noted, but there were key taxa that had differential abundance in either Healthy vs COPD and/or TSCOPD vs. BMSCOPD. Genera such as Actinomyces, Actinobacillus, Megasphaera , Selenomonas, and Corynebacterium were significantly higher in COPD subjects. This study suggests that microbial community undergoes dysbiosis which may further contribute to the progression of disease. Thus, it is important to identify etiological agents for such a polymicrobial alterations which contribute highly to the disease manifestation.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-020-02155-9