Impact of Ipsilateral Supraclavicular Lymph Node Dissection (ISLND) for Breast Cancer Patients and a Nomogram for Predicting Ipsilateral Supraclavicular Pathological Complete Response (ispCR)

• Published in: Annals of surgical oncology 2021-09, Vol.28 (9), p.5098-5109
• Main Authors: Lv, Minhao, Li, Juntao, Guo, Huihui, Wang, Chao, Tian, Peiqi, Ma, Youzhao, Chen, Xiuchun, Luo, Suxia
• Format: Article
• Language: English
• Subjects: Breast cancer; Breast Oncology; Chemotherapy; Clavicle; Lymph nodes; Lymphatic system; Medical prognosis; Medicine; Medicine & Public Health; Metastases; Metastasis; Nomograms; Oncology; Patients; Radiation therapy; Surgery; Surgical Oncology; Survival
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-020-09548-6

Background The purpose of this study was to evaluate the impact of ipsilateral supraclavicular lymph node dissection (ISLND) on the outcomes of breast cancer patients with ipsilateral supraclavicular lymph node metastasis (ISLNM), and to evaluate the prognostic value of ipsilateral supraclavicular pathological complete response (ispCR). Meanwhile, a nomogram was constructed to predict ispCR. Methods We retrospectively reviewed the medical documents of 353 patients with ISLNM but no distant metastasis at presentation. Based on whether ISLND was performed, patients were divided into radiotherapy (RT) and ISLND + RT groups. The impact of ISLND was evaluated after propensity score matching, and the prognostic value of ispCR was also analyzed. A nomogram to predict the probability of ispCR was constructed based on clinicopathologic variables. Results After propensity score matching, we found that the use of ISLND was associated with a higher rate of ipsilateral supraclavicular relapse-free survival (ISRFS; p