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Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer
Background This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR...
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| Published in: | The American surgeon 2022-06, Vol.88 (6), p.1256-1262 |
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| container_title | The American surgeon |
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| creator | Uludag, Server Sezgin Sanli, Ahmet Necati Zengin, Abdullah Kagan Ozcelik, Mehmet Faik |
| description | Background
This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated.
Methods
This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients.
Results
LDH (P < .001), NLR (P < .001), PLR (P < .05), CRP/albumin (P < .01), and neutrophil/albumin (P < .01) were significantly higher, while monocyte count (P < .05) and PNI (P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: −.568, P < .001).
Conclusions
Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer. |
| doi_str_mv | 10.1177/0003134821995059 |
| format | article |
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This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated.
Methods
This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients.
Results
LDH (P < .001), NLR (P < .001), PLR (P < .05), CRP/albumin (P < .01), and neutrophil/albumin (P < .01) were significantly higher, while monocyte count (P < .05) and PNI (P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: −.568, P < .001).
Conclusions
Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.]]></description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/0003134821995059</identifier><identifier>PMID: 33596111</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Albumin ; Albumins ; Biomarkers ; Blood platelets ; Blood tests ; Cancer ; Colon ; Colon cancer ; Colonic Neoplasms - surgery ; Colorectal cancer ; Hematology ; Humans ; Immunology ; Inflammation ; Laboratories ; Leukocyte Count ; Leukocytes (neutrophilic) ; Localization ; Lymphocytes ; Medical records ; Metastases ; Metastasis ; Monocytes ; Mortality ; Neutrophils ; NMR ; Nuclear magnetic resonance ; Nutrition assessment ; Patients ; Platelets ; Prognosis ; Retrospective Studies ; Subgroups ; Tumors</subject><ispartof>The American surgeon, 2022-06, Vol.88 (6), p.1256-1262</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-ea6f6e6966be4fe2f98bdb3508ea02ad7b78927e2f17f0865414ddf1ffa3974c3</citedby><cites>FETCH-LOGICAL-c365t-ea6f6e6966be4fe2f98bdb3508ea02ad7b78927e2f17f0865414ddf1ffa3974c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923,79134</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33596111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uludag, Server Sezgin</creatorcontrib><creatorcontrib>Sanli, Ahmet Necati</creatorcontrib><creatorcontrib>Zengin, Abdullah Kagan</creatorcontrib><creatorcontrib>Ozcelik, Mehmet Faik</creatorcontrib><title>Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description><![CDATA[Background
This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated.
Methods
This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients.
Results
LDH (P < .001), NLR (P < .001), PLR (P < .05), CRP/albumin (P < .01), and neutrophil/albumin (P < .01) were significantly higher, while monocyte count (P < .05) and PNI (P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: −.568, P < .001).
Conclusions
Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.]]></description><subject>Albumin</subject><subject>Albumins</subject><subject>Biomarkers</subject><subject>Blood platelets</subject><subject>Blood tests</subject><subject>Cancer</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colorectal cancer</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Leukocyte Count</subject><subject>Leukocytes (neutrophilic)</subject><subject>Localization</subject><subject>Lymphocytes</subject><subject>Medical records</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Monocytes</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nutrition assessment</subject><subject>Patients</subject><subject>Platelets</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Subgroups</subject><subject>Tumors</subject><issn>0003-1348</issn><issn>1555-9823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kM1LwzAYh4Mobk7vniTgxUs1ab6aow4_BpMdpueStm9GZ9vMpD3svzdjU0HwkpD8nveX8CB0ScktpUrdEUIYZTxLqdaCCH2ExlQIkegsZcdovIuTXT5CZyGs45FLQU_RiDGhJaV0jBbLbeihrUs862xj2tb0zm_xQ-1a4z_AB2wCXg7eu5XpAb8eLq3zeNmbFeC6w1PXuLiargR_jk6saQJcHPYJen96fJu-JPPF82x6P09KJkWfgJFWgtRSFsAtpFZnRVUwQTIwJDWVKlSmUxUDqizJpOCUV5Wl1hqmFS_ZBN3sezfefQ4Q-rytQwlNYzpwQ8hTrilRUQuN6PUfdO0G38Xf5amUWmueCRIpsqdK70LwYPONr6ODbU5JvpOd_5UdR64OxUPRQvUz8G03AskeCNHU76v_Fn4BJTuFoQ</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Uludag, Server Sezgin</creator><creator>Sanli, Ahmet Necati</creator><creator>Zengin, Abdullah Kagan</creator><creator>Ozcelik, Mehmet Faik</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202206</creationdate><title>Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer</title><author>Uludag, Server Sezgin ; Sanli, Ahmet Necati ; Zengin, Abdullah Kagan ; Ozcelik, Mehmet Faik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-ea6f6e6966be4fe2f98bdb3508ea02ad7b78927e2f17f0865414ddf1ffa3974c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Albumin</topic><topic>Albumins</topic><topic>Biomarkers</topic><topic>Blood platelets</topic><topic>Blood tests</topic><topic>Cancer</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - surgery</topic><topic>Colorectal cancer</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Laboratories</topic><topic>Leukocyte Count</topic><topic>Leukocytes (neutrophilic)</topic><topic>Localization</topic><topic>Lymphocytes</topic><topic>Medical records</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Monocytes</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nutrition assessment</topic><topic>Patients</topic><topic>Platelets</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Subgroups</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uludag, Server Sezgin</creatorcontrib><creatorcontrib>Sanli, Ahmet Necati</creatorcontrib><creatorcontrib>Zengin, Abdullah Kagan</creatorcontrib><creatorcontrib>Ozcelik, Mehmet Faik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uludag, Server Sezgin</au><au>Sanli, Ahmet Necati</au><au>Zengin, Abdullah Kagan</au><au>Ozcelik, Mehmet Faik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer</atitle><jtitle>The American surgeon</jtitle><addtitle>Am Surg</addtitle><date>2022-06</date><risdate>2022</risdate><volume>88</volume><issue>6</issue><spage>1256</spage><epage>1262</epage><pages>1256-1262</pages><issn>0003-1348</issn><eissn>1555-9823</eissn><abstract><![CDATA[Background
This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated.
Methods
This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients.
Results
LDH (P < .001), NLR (P < .001), PLR (P < .05), CRP/albumin (P < .01), and neutrophil/albumin (P < .01) were significantly higher, while monocyte count (P < .05) and PNI (P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: −.568, P < .001).
Conclusions
Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.]]></abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>33596111</pmid><doi>10.1177/0003134821995059</doi><tpages>7</tpages></addata></record> |
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| subjects | Albumin Albumins Biomarkers Blood platelets Blood tests Cancer Colon Colon cancer Colonic Neoplasms - surgery Colorectal cancer Hematology Humans Immunology Inflammation Laboratories Leukocyte Count Leukocytes (neutrophilic) Localization Lymphocytes Medical records Metastases Metastasis Monocytes Mortality Neutrophils NMR Nuclear magnetic resonance Nutrition assessment Patients Platelets Prognosis Retrospective Studies Subgroups Tumors |
| title | Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer |
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