HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil

Lymphoepithelial-like carcinoma is a rare malignancy characterized by lack of cellular differentiation and associated nonneoplastic lymphoplasmacytic cell infiltrate that is rarely seen in the colon. Although many cases are associated with EBV infection, HPV may be present in LELC arising in sites k...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2021-06, Vol.14 (3), p.810-814
Main Authors: Kopparthy, Pallavi, Chaffin, Joanna, Feely, Michael M., Parekh, Hiral D.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Surgical Oncology
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Description
Summary:Lymphoepithelial-like carcinoma is a rare malignancy characterized by lack of cellular differentiation and associated nonneoplastic lymphoplasmacytic cell infiltrate that is rarely seen in the colon. Although many cases are associated with EBV infection, HPV may be present in LELC arising in sites known for HPV-driven malignancies, like the anogenital region. We report a case of lymphoepithelial-like carcinoma mimicking a rectal tonsil in a 51-year-old female. Attentive evaluation must be taken to identify this tumor in locations where prominent lymphoid stroma is an expected finding.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-021-01362-1