miR-29 family: A potential therapeutic target for cardiovascular disease

Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortality worldwide. Evidence shows that miRNA plays an important role in the pathogenesis of CVD. miR-29 family is one of miRNA, and over the past decades,...

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Bibliographic Details
Published in:Pharmacological research 2021-04, Vol.166, p.105510-105510, Article 105510
Main Authors: Liu, Meng-Nan, Luo, Gang, Gao, Wan-Jiao, Yang, Si-Jin, Zhou, Hua
Format: Article
Language:English
Subjects:
Animals
Cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - genetics
Cardiovascular Diseases - pathology
Cardiovascular Diseases - therapy
Fibrosis
Gene Expression Regulation
Humans
MicroRNA
MicroRNAs - analysis
MicroRNAs - genetics
MiR-29 family
Myocardial fibrosis
Myocardium - pathology
Prognosis
Therapeutic target
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Summary:Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortality worldwide. Evidence shows that miRNA plays an important role in the pathogenesis of CVD. miR-29 family is one of miRNA, and over the past decades, many studies have demonstrated that miR-29 is involved in maintaining the integrity of arteries and in the regulation of atherosclerosis, especially in the process of myocardial fibrosis. Besides, heart failure, myocardial fibrosis and myocardial infarction are inseparable from the regulatory role of miR-29. Here, we comprehensively review recent studies regarding miR-29 and CVD, illustrate the possibility of miR-29 as a potential marker for prevention, treatment and prognostic observation. •miR-29 plays an important role in cardiovascular disease, and its regulatory function is almost omni-directional.•The role of miR-29 in myocardial fibrosis is currently a hot topic and he influence of the miR-29 family on fibrocyte activation and extracellular matrix overproduction have been studied in depth.•Both circulating miR-29 and miR-29 in tissues or cells are associated with the occurrence and development of cardiovascular diseases.•The therapeutic effect of miR-29 has been extensively studied, but its role in prevention and prognosis of disease remains to be proved.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2021.105510