Identification of a new class of HBV capsid assembly modulator

The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. Herein is described the identification and hit to lead SAR of a novel series of pyrazolo piperidine HBV capsid assembly modulators. [Display omitted] The HBV core protein is a druggable targe...

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Published in:Bioorganic & medicinal chemistry letters 2021-05, Vol.39, p.127848-127848, Article 127848
Main Authors: Kuduk, Scott D., Stoops, Bart, Alexander, Richard, Lam, Angela M., Espiritu, Christine, Vogel, Robert, Lau, Vincent, Klumpp, Klaus, Flores, Osvaldo A., Hartman, George D.
Format: Article
Language:English
Subjects:
Capsid
HBV
Modulator
Urea
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container_title Bioorganic & medicinal chemistry letters
container_volume 39
creator Kuduk, Scott D.
Stoops, Bart
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description The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. Herein is described the identification and hit to lead SAR of a novel series of pyrazolo piperidine HBV capsid assembly modulators. [Display omitted] The HBV core protein is a druggable target of interest due to the multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly has shown efficacy in clinical trials. Herein is described the identification and hit to lead SAR of a novel series of pyrazolo piperidine HBV capsid assembly modulators.
doi_str_mv 10.1016/j.bmcl.2021.127848
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subjects Capsid
HBV
Modulator
Urea
title Identification of a new class of HBV capsid assembly modulator
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