Systemic immune-inflammation index predicts no-reflow phenomenon after primary percutaneous coronary intervention

Systemic immune-inflammation index (SII), on the basis of lymphocyte, neutrophil and platelet counts had been published to be a good prognostic factor in coronary artery disease. Nevertheless, the prognostic value of Systemic immune-inflammation index (SII) in a condition of no-reflow phenomenon (NR...

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Bibliographic Details
Published in:Acta Cardiologica 2022-01, Vol.77 (1), p.59-65
Main Authors: Esenboğa, Kerim, Kurtul, Alparslan, Yamantürk, Yakup Yunus, Tan, Türkan Seda, Tutar, Durmuş Eralp
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Humans
Inflammation
Neutrophils
no-reflow phenomenon
No-Reflow Phenomenon - diagnosis
No-Reflow Phenomenon - etiology
Percutaneous Coronary Intervention - adverse effects
ST Elevation Myocardial Infarction - diagnosis
ST Elevation Myocardial Infarction - surgery
ST segment elevation
systemic immune-inflammation index
thrombus burden
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Summary:Systemic immune-inflammation index (SII), on the basis of lymphocyte, neutrophil and platelet counts had been published to be a good prognostic factor in coronary artery disease. Nevertheless, the prognostic value of Systemic immune-inflammation index (SII) in a condition of no-reflow phenomenon (NRP) remains inconsistent, we evaluated the SII as a simple calculated tool for predicting the NRP among patients with STEMI who underwent primary percutaneus coronary intervention (PCI). 510 consecutive acute STEMI patients who underwent primary PCI within 12 h from symptom onset from October 2015 to January 2020 were enrolled in our study. The receiver-operating characteristic (ROC) curve was used to determine the cut-off value of SII to predict the no-reflow. Multivariate stepwise logistic regression, including covariates found to have a significant association with NRP in univariate analysis, was used to identify independent predictors of no-reflow. A ROC curve analysis showed that the best cut-off value of SII for predicting no-reflow was 1028, with sensitivity and specificity of 79% and 70, respectively (AUC, 0.839; 95% CI 0.797-0.881). An ROC curve comparison analysis was performed to compare the SII with NLR and PLR. Multivariate analysis revealed that SII ≥1028 value (OR = 6.622, 95% confidence interval (CI): 3.802-11.627, p 
ISSN:0001-5385
0373-7934
1784-973X
DOI:10.1080/00015385.2021.1884786