Recent advances in nanomaterial-based augmented sonodynamic therapy of cancer

With interest in non-invasiveness and safety in cancer treatment, sonodynamic therapy (SDT) has emerged as a promising alternative to conventional cancer therapies. SDT offers safety and cost-effectiveness and exhibits a broad application range that is superior to photodynamic therapy. However, the...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (23), p.2854-2866
Main Authors: Um, Wooram, , Lee, Jeongjin, Kim, Chan Ho, You, Dong Gil, Park, Jae Hyung
Format: Article
Language:English
Subjects:
Cancer
Nanomaterials
Photodynamic therapy
Safety
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Summary:With interest in non-invasiveness and safety in cancer treatment, sonodynamic therapy (SDT) has emerged as a promising alternative to conventional cancer therapies. SDT offers safety and cost-effectiveness and exhibits a broad application range that is superior to photodynamic therapy. However, the insufficient reactive oxygen species (ROS) production of current sonosensitizers has hindered its clinical application to date. In this review, the ROS-generation mechanism in SDT and the limitations of current sonosensitizers are briefly reviewed. Also, highlighted are recent nanomaterial-based SDT strategies to improve the efficiency of sonosensitizers, amplify oxidative stress, and elicit antitumor immunity. This review focuses on recent advances in augmented sonodynamic therapy (SDT) using engineered nanomaterials, and the mechanism of SDT for discussing future perspectives.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc07750j