CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene

Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP . We a...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2021-03, Vol.48 (3), p.2117-2122
Main Authors: Sadeghi, Hossein, Esmkhani, Sahra, Pirjani, Reihaneh, Amin-Beidokhti, Mona, Gholami, Milad, Azizi Tabesh, Ghasem, Ghasemi, Mohammad Reza, Gachkar, Latif, Mirfakhraie, Reza
Format: Article
Language:English
Subjects:
Adult
Angiogenesis
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Biopsy
Case-Control Studies
CREB-binding protein
CREB-Binding Protein - genetics
CREB-Binding Protein - metabolism
Cyclic AMP response element-binding protein
Female
Fetus - pathology
Fetuses
Gene expression
Gene Expression Regulation
Histology
Humans
Hypoxia
Life Sciences
Morphology
Neonates
Original Article
Placenta
Placenta - metabolism
Placenta - pathology
Polymerase chain reaction
Pre-eclampsia
Pre-Eclampsia - genetics
Preeclampsia
Pregnancy
Pregnancy complications
Protein Interaction Maps
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP . We aimed to compare the expression level of the CERBBP gene between preeclamptic and healthy placenta in our study. The expression level of CREBBP gene was evaluated in a total of one hundred placental biopsies from PE patients and healthy pregnant women after delivery using quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, the differential expression of CREBBP was assessed between the maternal and fetal sides of the placenta. Expression of the CREBBP gene was higher in preeclampsia patients compared with the controls (Fold change = 2.158; P  = 0.018). Moreover, the gene expression was slightly higher in the fetal side of the placenta, although it was not significantly different (Fold change = 1.713, P  = 0.254). Our findings show a role for CREBBP in the pathogenesis of PE. Due to the important role of CREBBP in angiogenesis and hypoxia, the gene may serve as a promising target in future studies.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06215-1