Leakage index on ultra-widefield fluorescence angiography in different regions of retina and its correlation with cystoid macular edema in central retinal vein occlusion eyes

• Published in: Graefe's archive for clinical and experimental ophthalmology 2021-08, Vol.259 (8), p.2149-2156
• Main Authors: Wang, Xiaoling, Sun, Gongpeng, Yi, Zuohuizi, Xu, A’min, He, Lu, Jiang, Jingwen, Zheng, Hongmei, Chen, Changzheng
• Format: Article
• Language: English
• Subjects: Angiography; Edema; Eye; Ischemia; Leakage; Medical imaging; Medicine; Medicine & Public Health; Occlusion; Ophthalmology; Retina; Retinal Disorders
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-021-05126-y

Purpose To investigate the relationship between leakage index on ultra-widefield fluorescence angiography (UWFFA) in different regions of retina and its correlation with cystoid macular edema (CME) in central retinal vein occlusion (CRVO) eyes. Methods Patients with naïve non-ischemic CRVO that had undergone UWFFA were identified. UWFFA images in the late phase were used to analyze the leakage index, which was performed by a semi-automatic method using ImageJ. The UWFFA images were subdivided into four regions by concentric circles centered on the macula for analysis. Optical coherence tomography (OCT) images were used to identify the presence of CME and obtain central macular thickness (CMT). Results A total of 57 eyes from 57 CRVO patients were analyzed in this study, including 43 eyes with CME and 14 eyes without CME. The leakage index in panretinal, peri-macular area (PMA), and near-peripheral area (NPA) was significantly different between eyes with CME and eyes without CME. Leakage index of PMA, NPA, mid-peripheral area (MPA), and panretinal area was significantly correlated with CMT, particularly the PMA. Conclusions The distribution of leakage is different between patients with CME and patients without CME. The contribution of leakage index in different regions to CME was different, most predominant in PMA and NPA, and the closer to the center of the macula, the stronger the correlation between leakage index and CMT. A linear correlation was observed between CMT and the leakage index of panretinal area and all regions except far-peripheral area (FPA).