The prognostic significance of lymphovascular tumor invasion in localized high‐grade osteosarcoma: Outcomes of a single institution over 10 years

Backgrounds and Objectives Lymphovascular invasion (LVI) has shown evidence of an association with worse survival in high‐grade osteosarcoma patients. The purpose of this investigation was to prognosticate LVI as a predictor of survival. Methods This was a retrospective review of high‐grade, localiz...

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Bibliographic Details
Published in:Journal of surgical oncology 2021-06, Vol.123 (7), p.1624-1632
Main Authors: Gusho, Charles A., Miller, Ira, Clayton, Bishir, Colman, Matthew W., Gitelis, Steven, Blank, Alan T.
Format: Article
Language:English
Subjects:
Bone cancer
lymphovascular invasion
Medical prognosis
Mortality
osteosarcoma
outcomes
prognosis
Sarcoma
survival
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Summary:Backgrounds and Objectives Lymphovascular invasion (LVI) has shown evidence of an association with worse survival in high‐grade osteosarcoma patients. The purpose of this investigation was to prognosticate LVI as a predictor of survival. Methods This was a retrospective review of high‐grade, localized osteosarcoma patients over a consecutive 10‐year period. Proportional hazards regression was used to identify prognostic factors. Cumulative mortality incidence was estimated with recurrence as a competing risk. Results Forty‐two cases with a median follow‐up of 64 months (range, 6–158 months) were reviewed. LVI was present in 21.4% (n = 9) cases. The five‐ and ten‐year survivals in LVI (+) were 40% and 20%, compared to 93% and 81% in LVI (−), respectively (p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26445