Causal associations of waist circumference and waist-to-hip ratio with type II diabetes mellitus: new evidence from Mendelian randomization

Type II diabetes mellitus (T2DM) is a metabolic disease with high incidence, which has seriously affected human life and health. The associations among waist circumference (WC), waist-to-hip ratio (WHR), and T2DM were discovered in observational studies. However, the causality of these associations...

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Published in:Molecular genetics and genomics : MGG 2021-05, Vol.296 (3), p.605-613
Main Authors: Li, Kexin, Feng, Tianyu, Wang, Lijuan, Chen, Yang, Zheng, Pingping, Pan, Pan, Wang, Min, Binnay, Isaac T. S., Wang, Yingshuang, Chai, Ruiyu, Liu, Siyu, Li, Bo, Yao, Yan
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biochemistry
Biomedical and Life Sciences
Diabetes
Diabetes mellitus
Genetic diversity
Genome-wide association studies
Genomes
Hip
Human Genetics
Life Sciences
Metabolic disorders
Microbial Genetics and Genomics
Original Article
Plant Genetics and Genomics
Single-nucleotide polymorphism
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Summary:Type II diabetes mellitus (T2DM) is a metabolic disease with high incidence, which has seriously affected human life and health. The associations among waist circumference (WC), waist-to-hip ratio (WHR), and T2DM were discovered in observational studies. However, the causality of these associations still remains unknown. The present study aims to apply two-sample Mendelian randomization (TSMR) using genetic variants as instrumental variables (IVs) to evaluate the causality among WC, WHR, and T2DM. The participants were from three independent studies in genome-wide association studies (GWAS) datasets, which included 127,997 Europeans for WC, 73,137 Europeans for WHR and 659,316 Europeans for T2DM. Furthermore, 16 were associated WC SNPs and eight were associated WHR SNPs as instrument variables were selected for TSMR using P  
ISSN:1617-4615
1617-4623
DOI:10.1007/s00438-020-01752-z