The effects of sponges soaked with chlorhexidine gluconate and metronidazole on safety of colonic anastomosis in an experimental model of peritonitis

• Published in: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 2021-03, Vol.27 (2), p.167-173
• Main Authors: Aksu, Ali, Bozan, Mehmet Buğra, Kutluer, Nizamettin, Kanat, Burhan Hakan, İlhan, Yavuz Selim, Türkoğlu, Ahmet, Dağlı, Adile Ferda, Ilhan, Nevin, Azak Bozan, Ayşe, Aksoy, Nurullah
• Format: Article
• Language: English
• Subjects: Abdomen; Albinism; Peritonitis
• ISSN: 1306-696X; 1307-7945
• DOI: 10.14744/tjtes.2020.46682

The present study aims to evaluate the use of the chlorhexidine gluconate and metronidazole impregnated compresses concerning anastomosis safety in the left colonic anastomosis in the presence of peritonitis. This study was conducted on 21 Wistar-Albino-rats divided into three equal groups. After median laparotomy, the whole layer of the left colon was cut 2 cm over the pelvic peritoneum. The faeces were spread around the injury for fecal contamination. Then, fasia and skin were closed with 3/0 silk. After one day period, relaparatomy was performed. The abdomen was cleared isotonic sodium chloride with impregnated material before starting colonic anastomosis in the first group and then double layer colonic anastomosis was performed. In the second Group-II, abdomen was cleared with the metronidazole impregnated compresses then double layer colonic anastomosis was performed. In the group-III, abdomen was cleared with the chlorhexidine gluconate impregnated compresses then double layer colonic anastomosis was performed. Tissue hydroksiproline levels and anastomosis bursting pressures were measured and histopathologic findings on the anastomosis line were evaluated on the postoperative tenth day by performing relaparatomy. The highest anastomosis bursting pressure was found in Group-III (p