Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction

The C57BL/6 mouse strain have been commonly used for the genetic background animal models and experimental research. There are several major sources of C57BL/6 substrains for the biomedical research community which display genetic and phenotypic differences. Previous studies have suggested that the...

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Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2021-04, Vol.53 (2), p.119-127
Main Authors: Zhou, Zhou, Liu, Zhiheng, Gao, Xu, Long, Qinqiang
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Animal models
Animals
Aorta
Biochemistry
Bioorganic Chemistry
Cardiac function
Chemistry
Chemistry and Materials Science
Congestive heart failure
Disease Models, Animal
Experimental research
Heart attacks
Histology
Male
Mice
Mice, Inbred C57BL
Mitochondria
Mitochondria - genetics
Morphology
Myocardial infarction
Myocardial Infarction - genetics
Organic Chemistry
Phenotypes
Respiration
Surgery
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Summary:The C57BL/6 mouse strain have been commonly used for the genetic background animal models and experimental research. There are several major sources of C57BL/6 substrains for the biomedical research community which display genetic and phenotypic differences. Previous studies have suggested that the varies in baseline of cardiovascular phenotypes as well as in response to pressure overload by transverse aortic constriction (TAC). To investigate whether there exist substrain specific differences in response to heart failure post myocardial infarction (MI), consequently the impaired mitochondrial respiration, we performed MI surgery on two commonly used C57BL/6 substrains: C57BL/6J (BL/6J) and C57BL/6NCrl (BL/6N) mice. Subsequently, measurements about cardiac function, histology and mitochondrial respiration capacities were conducted to evaluate the differences. The data showed that C57BL/6J(BL/6J) mice is more resistant to the attack of MI, evidenced by lower mortality, less infarct size and better preserved cardiac function after MI, especially exhibited better mitochondrial respiration capacities, compared with the C57BL/6NCrl(BL/6N) mice.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-021-09884-6