Electrocatalytic evaluation of graphene oxide warped tetragonal t-lanthanum vanadate (GO@LaVO4) nanocomposites for the voltammetric detection of antifungal and antiprotozoal drug (clioquinol)

• Published in: Mikrochimica acta (1966) 2021-03, Vol.188 (3), p.102-102, Article 102
• Main Authors: Maheshwaran, Selvarasu, Akilarasan, Muthumariappan, Chen, Tse-Wei, Chen, Shen-Ming, Tamilalagan, Elayappan, Jiang, Ting-Yu, Alabdullkarem, Eman A., Soylak, Mustafa
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Electrochemical analysis; Electrons; Fungicides; Glassy carbon; Graphene; Lanthanum; Microengineering; Nanochemistry; Nanocomposites; Nanotechnology; Original Paper; Oxidation; Silver chloride; Vanadates; Voltammetry
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-021-04758-5

Metastable and rarely reported GO warped tetragonal phase t-lanthanum vanadate nanocomposites (GO@LaVO 4 -NCs) are reported for the sensitive electrochemical determination of antifungal drug Clioquinol (CQ). The hydrothermal method was adopted for synthesis of GO@LaVO 4 -NCs. The electrochemical performance of CQ was examined using cyclic voltammetry (CV) and differential plus voltammetry (DPV) at GO@LaVO 4 -NCs modified glassy carbon electrode (GCE). The electrocatalytic oxidation of CQ at the GO@LaVO 4 -NCs/GCE shows the highest anodic peak current at a potential of +0.51 V vs. Ag/AgCl. The proposed sensor provides excellent sensitivity of 4.1894 μA μM −1  cm −2 , a very low detection limit (LOD) of 2.44 nM, and a wide range of 25 nM to 438.52 μM towards CQ detection. Finally, the detection of CQ in biological media was successfully done using the GO@LaVO 4 -NCs/GCE and possesses recoveries of 94.67–98.0%. Graphical abstract