Fragile X syndrome in young females: Influence of executive function on the neurocognitive profile and adaptive behavior

• Published in: Research in developmental disabilities 2021-05, Vol.112, p.103912-103912, Article 103912
• Main Authors: Joga-Elvira, Lorena, Jacas, Carlos, Joga, María Luisa, Roche-Martínez, Ana, Brun-Gasca, Carme
• Format: Article
• Language: English
• Subjects: Adaptive behavior; Executive function; Females; Fragile-X-Syndrome; Neurocognitive profile
• ISSN: 0891-4222; 1873-3379
• DOI: 10.1016/j.ridd.2021.103912

The aim of this study is to describe the relationship between executive function (EF) and performance in different areas of the neurocognitive profile in young girls with Fragile-X-Syndrome (FXS). A neuropsychological assessment was carried out to 40 female participants aged 7–16 years (26 FXS, 14 control group). Regarding intellectual ability, in the group of girls with FXS 3.84 % of the participants obtained IQ scores in the range of moderate ID (IQ 35–40 to 49), 46.15 % in the range of mild ID (IQ 50–70), 38.46 % in the borderline range (IQ 70–85), and 11.53 % within the average range (IQ > 85). EF was found to have a greater influence on adaptive behavior, arithmetic ability, theory of mind, leadership, social integration, social competence, and anxiety/shyness in the group with FXS. In girls with FXS, EF showed a greater influence on adaptive behavior, arithmetic ability, and social domain.