Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp

A new bafilomycin derivative (1) and another seven known bafilomycins (2–8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activitie...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2021-02, Vol.84 (2), p.537-543
Main Authors: Xie, Xi, Lu, Shengsheng, Pan, Xiaoyan, Zou, Min, Li, Fangfang, Lin, Haixing, Hu, Jianan, Fan, Sheng, He, Jian
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - pharmacology
Dogs
Feces - microbiology
Influenza A virus - drug effects
Macrolides - pharmacology
Madin Darby Canine Kidney Cells
Proton-Translocating ATPases - antagonists & inhibitors
SARS-CoV-2 - drug effects
Streptomyces - metabolism
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Summary:A new bafilomycin derivative (1) and another seven known bafilomycins (2–8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.0c01243