Temporal trends in short and long-term outcomes after percutaneous coronary interventions among cancer patients

While mortality of acute coronary syndrome (ACS) is known to have steadily decline over the last decades, data are lacking regarding the complex sub-population of patients with both coronary artery disease and cancer. A large single-center percutaneous coronary intervention (PCI) registry was used t...

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Bibliographic Details
Published in:Heart and vessels 2021-09, Vol.36 (9), p.1283-1289
Main Authors: Nardi Agmon, Inbar, Perl, Leor, Bental, Tamir, Itzhaki Ben Zadok, Osnat, Vaknin-Assa, Hana, Codner, Pablo, Greenberg, Gabriel, Kornowski, Ran
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Biomedical Engineering and Bioengineering
Blood vessels
Cancer
Cardiac Surgery
Cardiology
Cardiovascular disease
Confidence intervals
Coronary artery
Coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - surgery
Heart diseases
Humans
Malignancy
Medicine
Medicine & Public Health
Mortality
Multivariate analysis
Myocardial Infarction
Neoplasms - complications
Original Article
Percutaneous Coronary Intervention - adverse effects
Regression analysis
Statistical analysis
Treatment Outcome
Vascular Surgery
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Summary:While mortality of acute coronary syndrome (ACS) is known to have steadily decline over the last decades, data are lacking regarding the complex sub-population of patients with both coronary artery disease and cancer. A large single-center percutaneous coronary intervention (PCI) registry was used to retrieve patients who had a known diagnosis of malignancy during PCI. Patients were divided into two groups according to the period in which PCI was performed (period 1: 2006–2011, period 2: 2012–2017). Cox regression hazard models were implemented to compare primary endpoint, defined as the composite outcomes of major adverse cardiac events (MACE) (which include cardiovascular death, myocardial infarction or target vessel revascularization) and secondary endpoint of all-cause mortality, between the two time periods. A total of 3286 patients were included, 1819 (55%) had undergone PCI in period 1, and 1467 (45%) in period 2. Both short- and long-term MACE and overall mortality were significantly lower in patients who underwent PCI at the latter period (2.3% vs. 4.3%, p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-021-01817-y