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New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

Chemical investigation of the ethanol extract of the branch and leaves of Illicium majus resulted in the isolation of four new phenylpropanoid glycosides (1–4) and one new phenolic glycoside (9), along with 13 known ones. Spectroscopic techniques were used to elucidate the structures of the new isol...

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Published in:Chemistry & biodiversity 2021-04, Vol.18 (4), p.e2001012-n/a
Main Authors: Li, Fang, Yan, Ting‐Ting, Fu, Ying‐Ying, Zhang, Nen‐Ling, Wang, Lei, Zhang, Yan‐Bing, Du, Juan, Liu, Ji‐Feng
Format: Article
Language:English
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Summary:Chemical investigation of the ethanol extract of the branch and leaves of Illicium majus resulted in the isolation of four new phenylpropanoid glycosides (1–4) and one new phenolic glycoside (9), along with 13 known ones. Spectroscopic techniques were used to elucidate the structures of the new isolates such as 3‐[(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐(hydroxymethyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl β‐D‐glucopyranoside (1), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐glucopyranoside (2), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐xylopyranoside (3), 3‐[(2R,3S)‐3‐({[2‐O‐(4‐O‐acetyl‐α‐L‐rhamnopyranosyl)‐β‐D‐xylopyranosyl]oxy}methyl)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl acetate (4), and 4‐(2‐hydroxyethyl)phenyl 3‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (9). Free radical scavenging activities of the isolates were elucidated through the DPPH assay method. The most active compounds, 1‐O‐caffeoyl‐β‐D‐glucopyranose (17) and soulieana acid 1 (18), exhibited moderate radical scavenging activities (IC50=37.7±4.4 μM and IC50=97.2±3.4 μM, respectively). The antibacterial activities of the isolates against Staphylococcus aureus and Escherichia coli were also assessed, and no activity was shown at the measured concentration (
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202001012