Development of a piperazinyl-NBD-based fluorescent probe and its dual-channel detection for hydrogen sulfide

To selectively detect H 2 S based on the thiolysis reaction of 7-nitro-1,2,3-benzoxadiazole (NBD), amines attracted increasing attention since NBD amine is regarded as a new H 2 S reaction site. Herein, a novel fluorescent probe, triphenylamine piperazine NBD (TPA-Pz-NBD), was developed. The results...

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Bibliographic Details
Published in:Analyst (London) 2021-04, Vol.146 (7), p.2138-2143
Main Authors: Pei, Shizeng, Li, Jiale, Zhang, Caihong, Liang, Wenting, Zhang, Guomei, Shi, Lihong, Wang, Wen, Shuang, Shaomin, Dong, Chuan
Format: Article
Language:English
Subjects:
Amines
Fluorescent indicators
Hydrogen sulfide
Selectivity
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Summary:To selectively detect H 2 S based on the thiolysis reaction of 7-nitro-1,2,3-benzoxadiazole (NBD), amines attracted increasing attention since NBD amine is regarded as a new H 2 S reaction site. Herein, a novel fluorescent probe, triphenylamine piperazine NBD (TPA-Pz-NBD), was developed. The results showed that it exhibited high selectivity towards H 2 S via fluorescence spectroscopy and solution color. Furthermore, TPA-Pz-NBD not only detected H 2 S by a dual-channel, turn-on fluorescence signal at 500 nm and turn-off fluorescence signal at 545 nm, respectively, but also displayed a wide detection range of 0-125 μM. In addition, living cell imaging results indicated that TPA-Pz-NBD holds potential for the detection of intracellular H 2 S. To selectively detect H 2 S, a novel dual-channel fluorescence probe, triphenylamine piperazine NBD (TPA-Pz-NBD), was developed based on the thiolysis reaction of NBD amine.
ISSN:0003-2654
1364-5528
DOI:10.1039/d1an00054c