Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs

Intervertebral disc degeneration (IVDD) is an age-related degenerative disease that is the main cause of low back pain. It seriously affects the quality of life of patients and places a heavy economic burden on families and society. The Wnt pathway plays an important role in the growth, development,...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2021-04, Vol.220, p.153366-153366, Article 153366
Main Authors: Wu, Zuo-Long, Xie, Qi-Qi, Liu, Tai-Cong, Yang, Xing, Zhang, Guang-Zhi, Zhang, Hai-Hong
Format: Article
Language:English
Subjects:
Apoptosis
Cell senescence
Extracellular matrix
Inflammation
Intervertebral disc degeneration
Wnt pathway
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Summary:Intervertebral disc degeneration (IVDD) is an age-related degenerative disease that is the main cause of low back pain. It seriously affects the quality of life of patients and places a heavy economic burden on families and society. The Wnt pathway plays an important role in the growth, development, and degeneration of intervertebral discs (IVDs). In the embryonic stage, the Wnt pathway participates in the growth and development of IVD by promoting the transformation of progenitor cells into notochord cells and the extension of the notochord. However, the activation of the Wnt pathway after birth promotes IVD cell senescence, apoptosis, and degradation of the extracellular matrix and induces the production of inflammatory factors, thereby accelerating the IVDD process. This article reviews the relationship between the Wnt pathway and IVD, emphasizing its influence on IVD growth, development, and degeneration. Targeting this pathway may become an effective strategy for the treatment of IVDD.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2021.153366