Changes in epidemiological characteristics and sero-prevalence against the varicella zoster virus in school-age children after the introduction of a national immunization program in Japan

A national immunization program using two doses of live attenuated varicella vaccine was introduced for children aged one to two years in Japan in October 2014. Varicella cases declined after 2014, and immunological status against varicella among vaccinated children changed in post-vaccination era....

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2021-08, Vol.17 (8), p.2494-2500
Main Authors: Yasui, Yosuke, Mitsui, Toshikatsu, Arima, Fujiyo, Uchida, Keiko, Inokuchi, Mikako, Tokumura, Mitsuaki, Nakayama, Tetsuo
Format: Article
Language:English
Subjects:
Chickenpox - epidemiology
Chickenpox - prevention & control
Chickenpox Vaccine
Child
elementary school students
epidemiology
Herpes Zoster - epidemiology
Herpes Zoster - prevention & control
Herpesvirus 3, Human
Humans
immunization program
Immunization Programs
Japan - epidemiology
Prevalence
Research Paper
Schools
sero-prevalence
Seroepidemiologic Studies
Vaccination
Varicella
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Summary:A national immunization program using two doses of live attenuated varicella vaccine was introduced for children aged one to two years in Japan in October 2014. Varicella cases declined after 2014, and immunological status against varicella among vaccinated children changed in post-vaccination era. A retrospective observational study of anti-varicella antibody seroprevalence, varicella vaccination status, and history of varicella among 528 students in the first grade of elementary school was conducted. The percentage of students who received at least a single dose of varicella vaccination increased from 67% (187 of 279 students) in 2007-2008 to 91% (226 of 249 students) in 2017. Students with a history of varicella decreased from 114 of 279 (41%) in 2007-2008 to 48 of 249 (19%, P
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2021.1890968