Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms

•PinX1 is an AR coactivator in the presence of agonist and antagonist ligands.•PinX1s promotes proliferation, migration and colony formation of PCa cells.•PinX1s promotes PCa via both AR-dependent and independent mechanisms. Coregulators play an important role in prostate cancer (PCa), modulating an...

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Published in:The Journal of steroid biochemistry and molecular biology 2021-06, Vol.210, p.105858-105858, Article 105858
Main Authors: Flores-Ramírez, Iván, Rivas-Torres, Miguel Ángel, Rodríguez-Dorantes, Mauricio, Gutiérrez-Sagal, Rubén, Baranda-Avila, Noemi, Langley, Elizabeth
Format: Article
Language:English
Subjects:
Androgen receptors
Androgens
Antagonists
Breast cancer
Coactivators
Coregulators
Gene expression
Nucleoli
PinX1
Prostate cancer
Transcription
Tumor cell lines
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Summary:•PinX1 is an AR coactivator in the presence of agonist and antagonist ligands.•PinX1s promotes proliferation, migration and colony formation of PCa cells.•PinX1s promotes PCa via both AR-dependent and independent mechanisms. Coregulators play an important role in prostate cancer (PCa), modulating androgen receptor (AR) action and representing a possible cause of androgen deprivation therapy failure. Pin2-interacting protein X1 (PinX1) is a nucleolar protein described as a steroid hormone receptor coregulator in breast cancer cell lines. In this work, we studied the effect of PinX1 on AR action in PCa. Our results demonstrate that PinX1 acts as an AR coactivator, increasing its transcriptional activity and target gene expression, as well as proliferation, migration and colony formation in PCa cell lines. These effects are observed in the presence and absence of AR agonist and antagonists, suggesting a possible androgen independent pathway for PinX1. We present the first oncogenic roles described for PinX1, acting as a coactivator of the AR.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2021.105858