Synthesis of biocompatible chitosan functionalized Ag decorated biocomposite for effective antibacterial and anticancer activity

The transition-metal dichalcogenides (TMDCs) like MoS2 and WS2 are a new and interesting class of materials and show considerable promise for use in a wide variety of fields, including nanomedicine for cancer. The eco-friendly, biodegradability, toxicity, and antimicrobial activity remain an open is...

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Bibliographic Details
Published in:International journal of biological macromolecules 2021-05, Vol.178, p.270-282
Main Authors: Kasinathan, Kasirajan, Marimuthu, Karunakaran, Murugesan, Balaji, Samayanan, Selvam, Panchu, Sarojini Jeeva, Swart, Hendrik C., Savariroyan, Stephen Rajkumar Inbanathan
Format: Article
Language:English
Subjects:
Antibacterial
Anticancer
Chitosan
MoS2
Silver
Two dimensional material
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Summary:The transition-metal dichalcogenides (TMDCs) like MoS2 and WS2 are a new and interesting class of materials and show considerable promise for use in a wide variety of fields, including nanomedicine for cancer. The eco-friendly, biodegradability, toxicity, and antimicrobial activity remain an open issue. Herein, we focused on the current demands of two dimensional (2D) TMDCs and produced high-quality, few-layered MoS2 nanosheets. Noble metal Ag incorporated into the 2D-CS/MoS2 NC by the liquid exfoliated process. The manufactured CS/MoS2/Ag hybrid NC showed excellent antibacterial activity against two microorganisms such as Gram-positive (21, 27, and 33 mm) and Gram-negative bacteria (23, 30, and 39 mm). The CS/MoS2/Ag hybrid NC was designed to have significant antibacterial activity against E.coli bacteria than S.aureus. Furthermore, the hybrid NC has a 74.18% cell inhibition against MCF-7 cancer cells. According to the literature relevant, it is the first extensive experimental analysis on the nano-bio interaction of 2D TMDCs nanomaterials in MCF-7 breast cancer cells. •Hydrothermal synthesis of CS/MoS2/Ag was made with a process of liquid exfoliation.•SEM and TEM confirmed spherical shaped Ag NPs is spread over the MoS2 nanosheet.•TGA confirms the addition of Ag NPs to increase the thermal stability up to 650 °C.•It shows excellent antimicrobial activity against E. coli than S. aureus bacteria.•The synergetic impact of CS/MoS2/Ag NC inhibits 74.18% of MCF-7 breast cancer cells.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2021.02.127