Maternal age affects the relationship of basal FSH and anti-Müllerian hormone concentrations with post-ICSI/IVF live birth

• Published in: Reproductive biomedicine online 2021-04, Vol.42 (4), p.748-756
• Main Authors: Buratini, Jose, Dal Canto, Mariabeatrice, De Ponti, Elena, Brambillasca, Fausta, Brigante, Claudio, Gippone, Silvana, Mignini Renzini, Mario, La Marca, Antonio
• Format: Article
• Language: English
• Subjects: Adult; Anti-Mullerian Hormone - blood; Anti-Müllerian hormone; Basal FSH; Birth Rate; Female; Follicle Stimulating Hormone - blood; Humans; ICSI; Infant, Newborn; IVF; Live birth; Maternal Age; Middle Aged; Pregnancy; Retrospective Studies; Sperm Injections, Intracytoplasmic - statistics & numerical data; Young Adult
• ISSN: 1472-6483; 1472-6491
• DOI: 10.1016/j.rbmo.2020.12.005

Does the association of basal FSH and anti-Müllerian hormone (AMH) concentrations with post-IVF/intracytoplasmic sperm injection (ICSI) live birth change with maternal age? A total of 2003 IVF/ICSI patients were stratified according to basal FSH/AMH in concordant favourable (CF; AMH >1 ng/ml and FSH ≤10 IU/l), concordant unfavourable (CU; AMH ≤1 ng/ml and FSH >10 IU/l), discordant with favourable AMH (DFA) and discordant with favourable FSH (DFF) groups, as well as according to age in pre-advanced maternal age (pre-AMA; 37, ≤40) and AMA-3 (>40). IVF/ICSI outcomes were compared among CF, CU, DFA and DFF groups, and the association of basal FSH and AMH concentrations with live birth was tested by univariate and multivariate analysis in total, pre-AMA and AMA groups, separately. Different outcome patterns were observed in discordant AMH/FSH groups from different age categories; favourable basal FSH concentrations were associated with higher delivery rates in pre-AMA patients, but with lower delivery rates in AMA groups. Within pre-AMA patients, DFF patients presented higher delivery rates but lower oocyte yield compared with DFA patients. In the univariate analysis, favourable AMH (P