Association between PD-L1 expression and 18F-FDG uptake in ovarian cancer

Objective Immunotherapy for programmed cell death 1 (PD-1) and its ligand, PD-L1, has been considered an effective treatment for ovarian cancer. 18 F-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is a widely used noninvasive imaging tool for diagno...

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Bibliographic Details
Published in:Annals of nuclear medicine 2021-04, Vol.35 (4), p.415-420
Main Authors: Choi, Yun Jung, Jo, KwanHyeong, Hwang, Sang Hyun, Jeong, YongHyu, Lee, Jung-Yun, Kim, Sunghoon, Kim, Sang Wun, Kim, Young Tae, Kang, Won Jun
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Cancer
Cell death
Computed tomography
Deoxyglucose
Fluorine isotopes
Imaging
Immunotherapy
Medicine
Medicine & Public Health
Nuclear Medicine
Original Article
Ovarian cancer
Patients
PD-1 protein
PD-L1 protein
Positron emission
Positron emission tomography
Radiology
Tomography
Tumors
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Summary:Objective Immunotherapy for programmed cell death 1 (PD-1) and its ligand, PD-L1, has been considered an effective treatment for ovarian cancer. 18 F-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is a widely used noninvasive imaging tool for diagnosing several cancers. In this study, we investigated the association between PD-L1 expression and the maximum standardized uptake value (SUVmax) using 18 F-FDG PET/CT. Methods We retrospectively analyzed clinical data of patients with ovarian cancer who underwent 18 F-FDG PET/CT. Patients were categorized into two groups according to PD-L1 expression results. The relationship between clinicopathological characteristics of patients with ovarian cancer and PD-L1 expression was examined. Results SUVmax was significantly higher in PD-L1-positive tumors than in PD-L1-negative tumors (16.1 ± 5.2 and 12.7 ± 7.0, respectively; p  = 0.026). There were no significant differences in age, histologic type, and tumor grade between the PD-L1-negative and PD-L1-positive groups. The receiver operating characteristic curve analysis demonstrated that the highest accuracy (61.8%) for predicting PD-L1 expression was obtained with an SUVmax cutoff value of 10.5. Conclusion There was a significant correlation between 18 F-FDG uptake and PD-L1 expression, suggesting a role of 18 F-FDG PET/CT in selecting ovarian cancer candidates for anti-PD-L1 antibody therapy.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-020-01571-7