Zn(OTf) 2 -catalyzed hydroamination of ynamides with aromatic amines

The Zn(OTf) -catalyzed hydroamination of ynamides 2a-2l with aromatic amines 1a-1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities. As a result, a variety of substituted amidine compounds 3...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2021-03, Vol.19 (11), p.2492-2501
Main Authors: Chen, Zhuo, Nie, Xiao-Di, Sun, Jian-Ting, Yang, Ai-Mei, Wei, Bang-Guo
Format: Article
Language:English
Subjects:
Amines
Crystallography
Functional groups
Regioselectivity
Substrates
Zinc
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Summary:The Zn(OTf) -catalyzed hydroamination of ynamides 2a-2l with aromatic amines 1a-1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities. As a result, a variety of substituted amidine compounds 3aa-3oa, 3ab-3al and 3pa-3rk were prepared in moderate to excellent yields and with high regioselectivities.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob02603d