Mitochondrial dysfunction defines T cell exhaustion

When T cells are exposed to continuous antigen stimulation, they become exhausted. Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic conditions in the intratumoral environment drive T ce...

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Bibliographic Details
Published in:Cell metabolism 2021-03, Vol.33 (3), p.470-472
Main Authors: Soto-Heredero, Gonzalo, Desdín-Micó, Gabriela, Mittelbrunn, María
Format: Article
Language:English
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Summary:When T cells are exposed to continuous antigen stimulation, they become exhausted. Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic conditions in the intratumoral environment drive T cell exhaustion, losing their cytotoxic function and anticancer effects.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2021.02.010