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Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography‐guided prostate biopsy
Objectives To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography‐guided prostate biopsy. Methods In this prospective interventional study, patients aged between 40 and 70 years with clinical indications...
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| Published in: | International journal of urology 2021-06, Vol.28 (6), p.683-686 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3771-7da1f4964df7e3a25a31b042358f6f87eae9ac45a2bb048a567800a458c1b6e83 |
| container_end_page | 686 |
| container_issue | 6 |
| container_start_page | 683 |
| container_title | International journal of urology |
| container_volume | 28 |
| creator | Shobeirian, Farzaneh Zerafatjou, Nikan Ghomi, Zahra Vafaei, Mohamad Darabi, Mohsen |
| description | Objectives
To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography‐guided prostate biopsy.
Methods
In this prospective interventional study, patients aged between 40 and 70 years with clinical indications for transrectal ultrasonography‐guided prostate biopsy were enrolled. Consecutive patients who received intraprostatic injection of amikacin coupled with oral ciprofloxacin were compared with historical controls receiving only prophylactic oral fluoroquinolones prior to biopsy. Patients were followed for 7 days after biopsy for signs and symptoms of infection.
Results
A total of 210 patients were included in this study (mean age 65.7 ± 7.8 years). Among patients without intraprostatic injection, nine (8.6%) developed infectious complications (lower urinary tract infection in seven patients, and prostatitis in two), which led to hospitalization in six patients (5.7%). None of the patients who received intraprostatic antibiotic injection developed infectious complications. The difference in the incidence of post‐transrectal ultrasonography‐guided biopsy infections between the two groups was statistically significant (P = 0.003).
Conclusion
Local intraprostatic antibiotic injection during transrectal ultrasonography‐guided prostate biopsy adjuvant to oral fluoroquinolones can significantly reduce the rate of post‐biopsy infectious complications. |
| doi_str_mv | 10.1111/iju.14541 |
| format | article |
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To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography‐guided prostate biopsy.
Methods
In this prospective interventional study, patients aged between 40 and 70 years with clinical indications for transrectal ultrasonography‐guided prostate biopsy were enrolled. Consecutive patients who received intraprostatic injection of amikacin coupled with oral ciprofloxacin were compared with historical controls receiving only prophylactic oral fluoroquinolones prior to biopsy. Patients were followed for 7 days after biopsy for signs and symptoms of infection.
Results
A total of 210 patients were included in this study (mean age 65.7 ± 7.8 years). Among patients without intraprostatic injection, nine (8.6%) developed infectious complications (lower urinary tract infection in seven patients, and prostatitis in two), which led to hospitalization in six patients (5.7%). None of the patients who received intraprostatic antibiotic injection developed infectious complications. The difference in the incidence of post‐transrectal ultrasonography‐guided biopsy infections between the two groups was statistically significant (P = 0.003).
Conclusion
Local intraprostatic antibiotic injection during transrectal ultrasonography‐guided prostate biopsy adjuvant to oral fluoroquinolones can significantly reduce the rate of post‐biopsy infectious complications.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.14541</identifier><identifier>PMID: 33665862</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Amikacin ; Antibiotics ; Biopsy ; Ciprofloxacin ; Fluoroquinolones ; infection prophylaxis ; Injection ; Prostate ; prostate biopsy ; Prostatitis ; Statistical analysis ; transrectal ultrasonography ; Ultrasonic imaging ; Urinary tract</subject><ispartof>International journal of urology, 2021-06, Vol.28 (6), p.683-686</ispartof><rights>2021 The Japanese Urological Association</rights><rights>2021 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3771-7da1f4964df7e3a25a31b042358f6f87eae9ac45a2bb048a567800a458c1b6e83</citedby><cites>FETCH-LOGICAL-c3771-7da1f4964df7e3a25a31b042358f6f87eae9ac45a2bb048a567800a458c1b6e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33665862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shobeirian, Farzaneh</creatorcontrib><creatorcontrib>Zerafatjou, Nikan</creatorcontrib><creatorcontrib>Ghomi, Zahra</creatorcontrib><creatorcontrib>Vafaei, Mohamad</creatorcontrib><creatorcontrib>Darabi, Mohsen</creatorcontrib><title>Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography‐guided prostate biopsy</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography‐guided prostate biopsy.
Methods
In this prospective interventional study, patients aged between 40 and 70 years with clinical indications for transrectal ultrasonography‐guided prostate biopsy were enrolled. Consecutive patients who received intraprostatic injection of amikacin coupled with oral ciprofloxacin were compared with historical controls receiving only prophylactic oral fluoroquinolones prior to biopsy. Patients were followed for 7 days after biopsy for signs and symptoms of infection.
Results
A total of 210 patients were included in this study (mean age 65.7 ± 7.8 years). Among patients without intraprostatic injection, nine (8.6%) developed infectious complications (lower urinary tract infection in seven patients, and prostatitis in two), which led to hospitalization in six patients (5.7%). None of the patients who received intraprostatic antibiotic injection developed infectious complications. The difference in the incidence of post‐transrectal ultrasonography‐guided biopsy infections between the two groups was statistically significant (P = 0.003).
Conclusion
Local intraprostatic antibiotic injection during transrectal ultrasonography‐guided prostate biopsy adjuvant to oral fluoroquinolones can significantly reduce the rate of post‐biopsy infectious complications.</description><subject>Amikacin</subject><subject>Antibiotics</subject><subject>Biopsy</subject><subject>Ciprofloxacin</subject><subject>Fluoroquinolones</subject><subject>infection prophylaxis</subject><subject>Injection</subject><subject>Prostate</subject><subject>prostate biopsy</subject><subject>Prostatitis</subject><subject>Statistical analysis</subject><subject>transrectal ultrasonography</subject><subject>Ultrasonic imaging</subject><subject>Urinary tract</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kc9q3DAQh0Vp6G63PeQFiqGX9uBEo3-Wj2FJky0LuSRnIdvyRotXdiybYMghj9Bn7JNkNrvpoRBdNCM-vtHwI-QU6BngOffb8QyEFPCBzEEIljIq2EcypznkqYaMzcjnGLeUAmegP5EZ50pJrdicPK3C0Nuub-NgB18mWHX3U2PLfWPD4Avf7ksftg7f2oBV0iHqwhCTMVSu37Q-bBK0hNgjY5tkbLCLbWg3qL6f_j7_2Yy-clVynOMStHZx-kJOattE9_V4L8jdr8vb5XW6vrlaLS_WacmzDNKsslCLXImqzhy3TFoOBW7Ipa5VrTNnXW5LIS0r8FlbqTJNqRVSl1Aop_mC_Dh4cf7D6OJgdj6WrmlscO0YDRO5lqAoAKLf_0O37dgH_J1hkisqGeMMqZ8HqsSFcOvadL3f2X4yQM0-EoORmNdIkP12NI7FzlX_yLcMEDg_AI--cdP7JrP6fXdQvgCve5nH</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Shobeirian, Farzaneh</creator><creator>Zerafatjou, Nikan</creator><creator>Ghomi, Zahra</creator><creator>Vafaei, Mohamad</creator><creator>Darabi, Mohsen</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography‐guided prostate biopsy</title><author>Shobeirian, Farzaneh ; Zerafatjou, Nikan ; Ghomi, Zahra ; Vafaei, Mohamad ; Darabi, Mohsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3771-7da1f4964df7e3a25a31b042358f6f87eae9ac45a2bb048a567800a458c1b6e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amikacin</topic><topic>Antibiotics</topic><topic>Biopsy</topic><topic>Ciprofloxacin</topic><topic>Fluoroquinolones</topic><topic>infection prophylaxis</topic><topic>Injection</topic><topic>Prostate</topic><topic>prostate biopsy</topic><topic>Prostatitis</topic><topic>Statistical analysis</topic><topic>transrectal ultrasonography</topic><topic>Ultrasonic imaging</topic><topic>Urinary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shobeirian, Farzaneh</creatorcontrib><creatorcontrib>Zerafatjou, Nikan</creatorcontrib><creatorcontrib>Ghomi, Zahra</creatorcontrib><creatorcontrib>Vafaei, Mohamad</creatorcontrib><creatorcontrib>Darabi, Mohsen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shobeirian, Farzaneh</au><au>Zerafatjou, Nikan</au><au>Ghomi, Zahra</au><au>Vafaei, Mohamad</au><au>Darabi, Mohsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography‐guided prostate biopsy</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2021-06</date><risdate>2021</risdate><volume>28</volume><issue>6</issue><spage>683</spage><epage>686</epage><pages>683-686</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography‐guided prostate biopsy.
Methods
In this prospective interventional study, patients aged between 40 and 70 years with clinical indications for transrectal ultrasonography‐guided prostate biopsy were enrolled. Consecutive patients who received intraprostatic injection of amikacin coupled with oral ciprofloxacin were compared with historical controls receiving only prophylactic oral fluoroquinolones prior to biopsy. Patients were followed for 7 days after biopsy for signs and symptoms of infection.
Results
A total of 210 patients were included in this study (mean age 65.7 ± 7.8 years). Among patients without intraprostatic injection, nine (8.6%) developed infectious complications (lower urinary tract infection in seven patients, and prostatitis in two), which led to hospitalization in six patients (5.7%). None of the patients who received intraprostatic antibiotic injection developed infectious complications. The difference in the incidence of post‐transrectal ultrasonography‐guided biopsy infections between the two groups was statistically significant (P = 0.003).
Conclusion
Local intraprostatic antibiotic injection during transrectal ultrasonography‐guided prostate biopsy adjuvant to oral fluoroquinolones can significantly reduce the rate of post‐biopsy infectious complications.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33665862</pmid><doi>10.1111/iju.14541</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0919-8172 |
| ispartof | International journal of urology, 2021-06, Vol.28 (6), p.683-686 |
| issn | 0919-8172 1442-2042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2498516011 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Amikacin Antibiotics Biopsy Ciprofloxacin Fluoroquinolones infection prophylaxis Injection Prostate prostate biopsy Prostatitis Statistical analysis transrectal ultrasonography Ultrasonic imaging Urinary tract |
| title | Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography‐guided prostate biopsy |
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