A real-world study of 176 cases with aplastic anemia treated in outpatient

To explore the diagnostic process and outcomes of patients with aplastic anemia (AA) who received outpatient treatment in a real-world setting. The diagnostic processes, treatment regimens, and outcomes of 176 patients with AA treated in outpatient centers from January 2018 to December 2019 were rev...

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Bibliographic Details
Published in:Zhōnghuá xuèyèxué zázhì 2021-01, Vol.42 (1), p.58
Main Authors: Zhang, L L, Yu, X, Fang, L W, Pan, H, Liang, Q, Zhao, J Y, Kuang, Z X, Shi, J
Format: Article
Language:Chinese
Subjects:
Anemia, Aplastic
Cyclosporine
Humans
Medicine, Chinese Traditional
Outpatients
Recurrence
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Summary:To explore the diagnostic process and outcomes of patients with aplastic anemia (AA) who received outpatient treatment in a real-world setting. The diagnostic processes, treatment regimens, and outcomes of 176 patients with AA treated in outpatient centers from January 2018 to December 2019 were reviewed. The median interval from the onset of symptoms to the first visit was 7 (5-120) months. Complaints during the first visit included bleeding (52.3% ) , anemia (51.7% ) , and infection (6.8% ) . For diagnosis, 168 patients (95.5% ) underwent bone marrow aspiration; however, only 22 of them (17.1% ) consented aspiration in multiple sites (sternum) . The completion rate of bone marrow biopsy was 85.1% (143/168) ; flow immunophenotype and karyotype analyses were performed on 59.5% (100/168) and 58.9% (99/168) of AA patients, respectively, and the culture of clonal forming units by bone marrow mononuclear cells was performed on 26.8% (45/168) of AA patients. The most preferred regimen was cyclosporine combined wit
ISSN:0253-2727
DOI:10.3760/cma.j.issn.0253-2727.2021.01.011