Effect of CRRT combined with low-flow ECMO on canines with ARDS and hypercapnia

• Published in: Journal of artificial organs 2021-09, Vol.24 (3), p.336-342
• Main Authors: Zhang, Kai, Ma, Mengqing, Pan, Hanchao, Chen, Yuyang, Hou, Daorong, Yin, Huiming
• Format: Article
• Language: English
• Subjects: Biomedical Engineering and Bioengineering; Carbon dioxide; Cardiac Surgery; Complications; Extracorporeal membrane oxygenation; Hypercapnia; Inflammation; Interleukin 6; Low flow; Mechanical ventilation; Medicine; Medicine & Public Health; Nephrology; Original Article; Oxygenation; Tumor necrosis factor-α; Ventilation
• ISSN: 1434-7229; 1619-0904
• DOI: 10.1007/s10047-021-01253-9

To observe the effect of continuous renal replacement therapy (CRRT) combined with low-flow extracorporeal membrane oxygenation (ECMO) of V–V mode on anti-inflammation, improving oxygenation and reducing P a CO 2 in canines with acute respiratory distress syndrome (ARDS) and hypercapnia. A total of 30 healthy adult canines were randomly divided into sham group ( n  = 10), ECMO (EC) group ( n  = 10) and CRRT + ECMO (CR + EC) group ( n  = 10). Sham group was only treated with invasive mechanical ventilation. EC group was also treated with ECMO. CR + EC group was treated with CRRT combined with low-flow ECMO of V–V mode besides invasive mechanical ventilation. The results showed that hazard ratio was lower in the CR + EC group. Inflammatory factors, OI values, and PaCO 2 levels were lower in the CR + EC group. There was no significant difference in the levels of MAP, CO and T among the three groups. No significant complications or death was developed in the three groups. Compared with ECMO group at T3, T6 and T9, IL-6 [(276.13 ± 8.32, 262.04 ± 7.15, 259.33 ± 7.31)ng/L VS (352.67 ± 19.24, 360.24 ± 23.58, 362.21 ± 25.24)ng/L] and TNF-α [(50.14 ± 1.75, 50.45 ± 1.81, 48.03 ± 1.24) ng/L VS (70.25 ± 3.02, 72.45 ± 3.25, 76.69 ± 2.18)ng/L] in CR + EC group were decreased ( P