Transcatheter Mitral Valve Implantation Systematic Review: Focus on Transseptal Approach and Mitral Annulus Calcification

• Published in: Current cardiology reports 2021-04, Vol.23 (4), p.37-37, Article 37
• Main Authors: Ben-Ali, W., Ibrahim, R., Rodès-Cabeau, J., von Bardeleben, R. S., Mylotte, D., Granada, J., Modine, T.
• Format: Article
• Language: English
• Subjects: Cardiac Catheterization; Cardiology; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Medicine; Medicine & Public Health; Mitral Valve - surgery; Mitral Valve Insufficiency - surgery; Section Editors; Structural Heart Disease (RJ Siegel and NC Wunderlich; Topical Collection on Structural Heart Disease; Treatment Outcome
• ISSN: 1523-3782; 1534-3170
• DOI: 10.1007/s11886-021-01466-7

Introduction This systematic review was performed to evaluate the results of transcatheter mitral valve implantation (TMVI) in the native mitral valve. Evidence acquisition Medline, EMBASE, and the Cochrane Central register were systematically searched for studies that reported results of TMVI in mitral valve regurgitation and/or stenosis and mitral annular calcification. To improve the sensitivity of the literature search, we performed citation chasing in Google Scholar, Scopus, and Web of Science. Evidence synthesis Twelve studies reporting results of TMVI in mitral regurgitation were retrieved and included 347 patients. The transseptal approach represented 28% of cases. Secondary mitral regurgitation was the predominant indication in 63% of cases. Thirty-day mortality was 11% and was lowered with the transseptal approach (7%). Technical success was 92%. Surgical conversion was needed in 5% of patients. Only one patient presented moderate to severe mitral regurgitation. These hemodynamic results were sustainable up to one year of follow-up. Three series focused on results of TMVI in mitral annulus calcification including 167 patients. Only nine patients were treated with TMVI dedicated prosthesis. Eighty-seven patients had their prosthesis delivered through a transseptal approach. Mitral stenosis was present in 63% of cases. Thirty-day mortality was 24%, and none with TMVI prosthesis. Technical success was achieved in 71% of cases and was improved by using TMVI prosthesis (89%). The main complication was left ventricular outflow tract obstruction (20%). Post procedural moderate to severe mitral regurgitation was observed in 4% of cases. Conclusion TMVI seems to be feasible, achieving good technical success and predictable and durable MR reduction.