Hypothalamic lesions in neuromyelitis optica spectrum disorders: exploring a scoring system based on magnetic resonance imaging

Purpose We propose a scoring system for early diagnosis of sleep abnormalities in neuromyelitis optica spectrum disorders (NMOSD) with hypothalamic lesions based on magnetic resonance imaging (MRI). Materials and methods We evaluated MRI features of 45 patients with hypothalamic lesions identified f...

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Bibliographic Details
Published in:Japanese journal of radiology 2021-07, Vol.39 (7), p.659-668
Main Authors: Luo, Wenjing, Fang, Ling, Wang, Zhanhang, Liu, Zifeng, Liao, Jinchi, Meng, Zhanao, Shen, Shishi, Liu, Baozhu, Li, Rui, Kermode, Allan G., Qiu, Wei
Format: Article
Language:English
Subjects:
Abnormalities
Confidence intervals
Correlation coefficient
Correlation coefficients
Diagnosis
Disorders
Hypothalamus
Imaging
Lesions
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Neuromyelitis
Nuclear Medicine
Original Article
Radiology
Radiotherapy
Regression analysis
Resonance
Sleep
Sleep and wakefulness
Sleepiness
Statistical analysis
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Summary:Purpose We propose a scoring system for early diagnosis of sleep abnormalities in neuromyelitis optica spectrum disorders (NMOSD) with hypothalamic lesions based on magnetic resonance imaging (MRI). Materials and methods We evaluated MRI features of 45 patients with hypothalamic lesions identified from two cohorts. Univariate logistic regression analysis identified factors associated with sleepiness, which were subsequently used to develop a scoring system. Interrater reliability was determined using intraclass correlation coefficient (ICC). Correlations between scores and clinical features were analyzed. Results In total, 48.9% of 45 patients with hypothalamic lesions exhibited sleepiness. The number of involved slices, maximum width/length of hypothalamic lesions, and boundaries extending beyond the hypothalamus were associated with sleepiness (all p  
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-021-01104-w