Recent Advances in the Treatment of Opioid Use Disorder

Purpose of Review Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States’ healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy. Recent Findings Recent advances in therapeutic options for OUD have shown prom...

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Bibliographic Details
Published in:Current pain and headache reports 2021-04, Vol.25 (4), p.23-23, Article 23
Main Authors: Kuppalli, Sumanth, Seth, Raghav, Orhurhu, Vwaire, Urits, Ivan, Kaye, Alan D., Hunter, Corey, Gulati, Amitabh, Adekoya, Peju, Kaye, Adam M., Jones, Mark R.
Format: Article
Language:English
Subjects:
Addictions
Alternative Treatments for Pain Medicine (M Jones
Anesthesiology
Behavior modification
Drug abuse
Drug addiction
Drug dosages
Drug withdrawal
Heroin
Internal Medicine
Medicine
Medicine & Public Health
Methadone
Narcotics
Neurosciences
Pain
Pain Medicine
Pharmacy
Section Editor
Topical Collection on Alternative Treatments for Pain Medicine
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Summary:Purpose of Review Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States’ healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy. Recent Findings Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments’ market viability. Summary This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.
ISSN:1531-3433
1534-3081
DOI:10.1007/s11916-021-00941-8