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Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome
Background We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis re...
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Published in: | Pediatric nephrology (Berlin, West) West), 2021-09, Vol.36 (9), p.2739-2746 |
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container_title | Pediatric nephrology (Berlin, West) |
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creator | Cobeñas, Carlos J. Lombardi, Laura L. Pereyra, Priscila De Rose, Emanuel Gogorza, María José Spizzirri, Ana Paula Ruscasso, Javier D. Ferradas, Soledad Luján Suárez, Ángela del Carmen Amoreo, Oscar R. Zalba, Javier H. Risso, Paula |
description | Background
We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis requirement and evaluate if hypoalbuminemia is associated with fecal protein losses.
Methods
We prospectively evaluated STEC-HUS patients treated at our institution from 9/2011 to 2/2019, analyzing the presence of HC, CNSd and dialysis requirement and SAL, SSL, leukocytes, hematocrit and α1-antitrypsin clearance.
Results
We evaluated 98 patients, with mean age of 33.3 months. SAL ≤ 29.5 g/l, > 24,600 leukocytes/mm
3
and hematocrit > 30% behave as independent prognostic markers for HC. SAL ≤ 28 g/l, > 25,200 leukocytes/mm
3
and hematocrit > 30% behave as prognostic markers for CNSd. SAL ≤ 31.6 g/l, > 13,800 leukocytes/mm
3
, hematocrit > 18.9% and hyponatremia (≤ 132 mEq/l) behave as prognostic markers for dialysis requirement. However, in multivariate logistic regression models, only hypoalbuminemia behaved as a risk factor for HC, CNSd and dialysis. α1-antitrypsin clearance was performed in 69 patients and was high in 9/69 (13%), only 4 with HC. No significant association was observed between α1-antitrypsin clearance and albuminemia (
χ
2
= 0.1076,
p
= 0.7429) as well as α1-antitrypsin clearance and HC (
χ
2
= 1.7892,
p
= 0.1810).
Conclusions
Almost all patients with HC had hypoalbuminemia, which behaves as a risk factor for HC, CNSd and dialysis requirement. No significant association was observed between elevated α1-antitrypsin clearance and hypoalbuminemia nor between elevated α1-antitrypsin clearance and HC. These findings could be related to the small number of evaluated patients. |
doi_str_mv | 10.1007/s00467-021-05017-8 |
format | article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2501266662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A672457002</galeid><sourcerecordid>A672457002</sourcerecordid><originalsourceid>FETCH-LOGICAL-c555t-5fa026889dd85cd16b65243339875735b242a0d0a66285478cde166f12d932363</originalsourceid><addsrcrecordid>eNp9kl1rFDEYhYNY7Lb6B7yQgFC8mTYfk4_xrizVCoVetEK9Ctkks5s6k6xJBtl_b7ZbrZXF5CKQ9zmHl8MB4C1GpxghcZYRarloEMENYgiLRr4AM9xS0uBO3r0EM9TROmrx3SE4yvkeISSZ5K_AIaUCE8nbGfh2uVlHPSym0Qc3ev0Raph8_g57bUpM0Ae41sW7UDL86csK3txezBudczReF2fhyo1x2BRv4JSqgYF5E2yKo3sNDno9ZPfm8T0GXz9d3M4vm6vrz1_m51eNYYyVhvUaES5lZ61kxmK-4Iy0lNJOCiYoW5CWaGSR5pxI1gpprMOc95jYjhLK6TH4sPNdp_hjcrmo0WfjhkEHF6esSI2G8HpIRd__g97HKYW6XaU4QYJhip-opR6c8qGPJWmzNVXnXJCWCYS2Xs0eaumCS3qIwfW-fj_jT_fw9dptansFJ38JVk4PZZXjMBUfQ34Okh1oUsw5uV6tkx912iiM1LYoalcUVYuiHoqiZBW9e4xiWozO_pH8bkYF6A7IdRSWLj1l9R_bX79gw98</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562075131</pqid></control><display><type>article</type><title>Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome</title><source>Springer Nature</source><creator>Cobeñas, Carlos J. ; Lombardi, Laura L. ; Pereyra, Priscila ; De Rose, Emanuel ; Gogorza, María José ; Spizzirri, Ana Paula ; Ruscasso, Javier D. ; Ferradas, Soledad Luján ; Suárez, Ángela del Carmen ; Amoreo, Oscar R. ; Zalba, Javier H. ; Risso, Paula</creator><creatorcontrib>Cobeñas, Carlos J. ; Lombardi, Laura L. ; Pereyra, Priscila ; De Rose, Emanuel ; Gogorza, María José ; Spizzirri, Ana Paula ; Ruscasso, Javier D. ; Ferradas, Soledad Luján ; Suárez, Ángela del Carmen ; Amoreo, Oscar R. ; Zalba, Javier H. ; Risso, Paula</creatorcontrib><description>Background
We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis requirement and evaluate if hypoalbuminemia is associated with fecal protein losses.
Methods
We prospectively evaluated STEC-HUS patients treated at our institution from 9/2011 to 2/2019, analyzing the presence of HC, CNSd and dialysis requirement and SAL, SSL, leukocytes, hematocrit and α1-antitrypsin clearance.
Results
We evaluated 98 patients, with mean age of 33.3 months. SAL ≤ 29.5 g/l, > 24,600 leukocytes/mm
3
and hematocrit > 30% behave as independent prognostic markers for HC. SAL ≤ 28 g/l, > 25,200 leukocytes/mm
3
and hematocrit > 30% behave as prognostic markers for CNSd. SAL ≤ 31.6 g/l, > 13,800 leukocytes/mm
3
, hematocrit > 18.9% and hyponatremia (≤ 132 mEq/l) behave as prognostic markers for dialysis requirement. However, in multivariate logistic regression models, only hypoalbuminemia behaved as a risk factor for HC, CNSd and dialysis. α1-antitrypsin clearance was performed in 69 patients and was high in 9/69 (13%), only 4 with HC. No significant association was observed between α1-antitrypsin clearance and albuminemia (
χ
2
= 0.1076,
p
= 0.7429) as well as α1-antitrypsin clearance and HC (
χ
2
= 1.7892,
p
= 0.1810).
Conclusions
Almost all patients with HC had hypoalbuminemia, which behaves as a risk factor for HC, CNSd and dialysis requirement. No significant association was observed between elevated α1-antitrypsin clearance and hypoalbuminemia nor between elevated α1-antitrypsin clearance and HC. These findings could be related to the small number of evaluated patients.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-021-05017-8</identifier><identifier>PMID: 33712864</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>a1-antitrypsin ; Albumin ; Central nervous system ; Central nervous system diseases ; Child, Preschool ; Colitis ; Complications and side effects ; Dialysis ; Escherichia coli infections ; Health aspects ; Hematocrit ; Hemodialysis ; Hemolytic uremic syndrome ; Hemolytic-Uremic Syndrome - complications ; Hemolytic-Uremic Syndrome - epidemiology ; Hemorrhage ; Humans ; Hypoalbuminemia - complications ; Hypoalbuminemia - epidemiology ; Hyponatremia ; Leukocytes ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatrics ; Regression analysis ; Renal Dialysis ; Risk Factors ; Shiga-Toxigenic Escherichia coli ; Urology</subject><ispartof>Pediatric nephrology (Berlin, West), 2021-09, Vol.36 (9), p.2739-2746</ispartof><rights>IPNA 2021</rights><rights>2021. IPNA.</rights><rights>COPYRIGHT 2021 Springer</rights><rights>IPNA 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-5fa026889dd85cd16b65243339875735b242a0d0a66285478cde166f12d932363</citedby><cites>FETCH-LOGICAL-c555t-5fa026889dd85cd16b65243339875735b242a0d0a66285478cde166f12d932363</cites><orcidid>0000-0002-8354-3195</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33712864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cobeñas, Carlos J.</creatorcontrib><creatorcontrib>Lombardi, Laura L.</creatorcontrib><creatorcontrib>Pereyra, Priscila</creatorcontrib><creatorcontrib>De Rose, Emanuel</creatorcontrib><creatorcontrib>Gogorza, María José</creatorcontrib><creatorcontrib>Spizzirri, Ana Paula</creatorcontrib><creatorcontrib>Ruscasso, Javier D.</creatorcontrib><creatorcontrib>Ferradas, Soledad Luján</creatorcontrib><creatorcontrib>Suárez, Ángela del Carmen</creatorcontrib><creatorcontrib>Amoreo, Oscar R.</creatorcontrib><creatorcontrib>Zalba, Javier H.</creatorcontrib><creatorcontrib>Risso, Paula</creatorcontrib><title>Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis requirement and evaluate if hypoalbuminemia is associated with fecal protein losses.
Methods
We prospectively evaluated STEC-HUS patients treated at our institution from 9/2011 to 2/2019, analyzing the presence of HC, CNSd and dialysis requirement and SAL, SSL, leukocytes, hematocrit and α1-antitrypsin clearance.
Results
We evaluated 98 patients, with mean age of 33.3 months. SAL ≤ 29.5 g/l, > 24,600 leukocytes/mm
3
and hematocrit > 30% behave as independent prognostic markers for HC. SAL ≤ 28 g/l, > 25,200 leukocytes/mm
3
and hematocrit > 30% behave as prognostic markers for CNSd. SAL ≤ 31.6 g/l, > 13,800 leukocytes/mm
3
, hematocrit > 18.9% and hyponatremia (≤ 132 mEq/l) behave as prognostic markers for dialysis requirement. However, in multivariate logistic regression models, only hypoalbuminemia behaved as a risk factor for HC, CNSd and dialysis. α1-antitrypsin clearance was performed in 69 patients and was high in 9/69 (13%), only 4 with HC. No significant association was observed between α1-antitrypsin clearance and albuminemia (
χ
2
= 0.1076,
p
= 0.7429) as well as α1-antitrypsin clearance and HC (
χ
2
= 1.7892,
p
= 0.1810).
Conclusions
Almost all patients with HC had hypoalbuminemia, which behaves as a risk factor for HC, CNSd and dialysis requirement. No significant association was observed between elevated α1-antitrypsin clearance and hypoalbuminemia nor between elevated α1-antitrypsin clearance and HC. These findings could be related to the small number of evaluated patients.</description><subject>a1-antitrypsin</subject><subject>Albumin</subject><subject>Central nervous system</subject><subject>Central nervous system diseases</subject><subject>Child, Preschool</subject><subject>Colitis</subject><subject>Complications and side effects</subject><subject>Dialysis</subject><subject>Escherichia coli infections</subject><subject>Health aspects</subject><subject>Hematocrit</subject><subject>Hemodialysis</subject><subject>Hemolytic uremic syndrome</subject><subject>Hemolytic-Uremic Syndrome - complications</subject><subject>Hemolytic-Uremic Syndrome - epidemiology</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hypoalbuminemia - complications</subject><subject>Hypoalbuminemia - epidemiology</subject><subject>Hyponatremia</subject><subject>Leukocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Shiga-Toxigenic Escherichia coli</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kl1rFDEYhYNY7Lb6B7yQgFC8mTYfk4_xrizVCoVetEK9Ctkks5s6k6xJBtl_b7ZbrZXF5CKQ9zmHl8MB4C1GpxghcZYRarloEMENYgiLRr4AM9xS0uBO3r0EM9TROmrx3SE4yvkeISSZ5K_AIaUCE8nbGfh2uVlHPSym0Qc3ev0Raph8_g57bUpM0Ae41sW7UDL86csK3txezBudczReF2fhyo1x2BRv4JSqgYF5E2yKo3sNDno9ZPfm8T0GXz9d3M4vm6vrz1_m51eNYYyVhvUaES5lZ61kxmK-4Iy0lNJOCiYoW5CWaGSR5pxI1gpprMOc95jYjhLK6TH4sPNdp_hjcrmo0WfjhkEHF6esSI2G8HpIRd__g97HKYW6XaU4QYJhip-opR6c8qGPJWmzNVXnXJCWCYS2Xs0eaumCS3qIwfW-fj_jT_fw9dptansFJ38JVk4PZZXjMBUfQ34Okh1oUsw5uV6tkx912iiM1LYoalcUVYuiHoqiZBW9e4xiWozO_pH8bkYF6A7IdRSWLj1l9R_bX79gw98</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Cobeñas, Carlos J.</creator><creator>Lombardi, Laura L.</creator><creator>Pereyra, Priscila</creator><creator>De Rose, Emanuel</creator><creator>Gogorza, María José</creator><creator>Spizzirri, Ana Paula</creator><creator>Ruscasso, Javier D.</creator><creator>Ferradas, Soledad Luján</creator><creator>Suárez, Ángela del Carmen</creator><creator>Amoreo, Oscar R.</creator><creator>Zalba, Javier H.</creator><creator>Risso, Paula</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8354-3195</orcidid></search><sort><creationdate>20210901</creationdate><title>Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome</title><author>Cobeñas, Carlos J. ; Lombardi, Laura L. ; Pereyra, Priscila ; De Rose, Emanuel ; Gogorza, María José ; Spizzirri, Ana Paula ; Ruscasso, Javier D. ; Ferradas, Soledad Luján ; Suárez, Ángela del Carmen ; Amoreo, Oscar R. ; Zalba, Javier H. ; Risso, Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-5fa026889dd85cd16b65243339875735b242a0d0a66285478cde166f12d932363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>a1-antitrypsin</topic><topic>Albumin</topic><topic>Central nervous system</topic><topic>Central nervous system diseases</topic><topic>Child, Preschool</topic><topic>Colitis</topic><topic>Complications and side effects</topic><topic>Dialysis</topic><topic>Escherichia coli infections</topic><topic>Health aspects</topic><topic>Hematocrit</topic><topic>Hemodialysis</topic><topic>Hemolytic uremic syndrome</topic><topic>Hemolytic-Uremic Syndrome - complications</topic><topic>Hemolytic-Uremic Syndrome - epidemiology</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Hypoalbuminemia - complications</topic><topic>Hypoalbuminemia - epidemiology</topic><topic>Hyponatremia</topic><topic>Leukocytes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Regression analysis</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><topic>Shiga-Toxigenic Escherichia coli</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cobeñas, Carlos J.</creatorcontrib><creatorcontrib>Lombardi, Laura L.</creatorcontrib><creatorcontrib>Pereyra, Priscila</creatorcontrib><creatorcontrib>De Rose, Emanuel</creatorcontrib><creatorcontrib>Gogorza, María José</creatorcontrib><creatorcontrib>Spizzirri, Ana Paula</creatorcontrib><creatorcontrib>Ruscasso, Javier D.</creatorcontrib><creatorcontrib>Ferradas, Soledad Luján</creatorcontrib><creatorcontrib>Suárez, Ángela del Carmen</creatorcontrib><creatorcontrib>Amoreo, Oscar R.</creatorcontrib><creatorcontrib>Zalba, Javier H.</creatorcontrib><creatorcontrib>Risso, Paula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cobeñas, Carlos J.</au><au>Lombardi, Laura L.</au><au>Pereyra, Priscila</au><au>De Rose, Emanuel</au><au>Gogorza, María José</au><au>Spizzirri, Ana Paula</au><au>Ruscasso, Javier D.</au><au>Ferradas, Soledad Luján</au><au>Suárez, Ángela del Carmen</au><au>Amoreo, Oscar R.</au><au>Zalba, Javier H.</au><au>Risso, Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>36</volume><issue>9</issue><spage>2739</spage><epage>2746</epage><pages>2739-2746</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis requirement and evaluate if hypoalbuminemia is associated with fecal protein losses.
Methods
We prospectively evaluated STEC-HUS patients treated at our institution from 9/2011 to 2/2019, analyzing the presence of HC, CNSd and dialysis requirement and SAL, SSL, leukocytes, hematocrit and α1-antitrypsin clearance.
Results
We evaluated 98 patients, with mean age of 33.3 months. SAL ≤ 29.5 g/l, > 24,600 leukocytes/mm
3
and hematocrit > 30% behave as independent prognostic markers for HC. SAL ≤ 28 g/l, > 25,200 leukocytes/mm
3
and hematocrit > 30% behave as prognostic markers for CNSd. SAL ≤ 31.6 g/l, > 13,800 leukocytes/mm
3
, hematocrit > 18.9% and hyponatremia (≤ 132 mEq/l) behave as prognostic markers for dialysis requirement. However, in multivariate logistic regression models, only hypoalbuminemia behaved as a risk factor for HC, CNSd and dialysis. α1-antitrypsin clearance was performed in 69 patients and was high in 9/69 (13%), only 4 with HC. No significant association was observed between α1-antitrypsin clearance and albuminemia (
χ
2
= 0.1076,
p
= 0.7429) as well as α1-antitrypsin clearance and HC (
χ
2
= 1.7892,
p
= 0.1810).
Conclusions
Almost all patients with HC had hypoalbuminemia, which behaves as a risk factor for HC, CNSd and dialysis requirement. No significant association was observed between elevated α1-antitrypsin clearance and hypoalbuminemia nor between elevated α1-antitrypsin clearance and HC. These findings could be related to the small number of evaluated patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33712864</pmid><doi>10.1007/s00467-021-05017-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8354-3195</orcidid><oa>free_for_read</oa></addata></record> |
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ispartof | Pediatric nephrology (Berlin, West), 2021-09, Vol.36 (9), p.2739-2746 |
issn | 0931-041X 1432-198X |
language | eng |
recordid | cdi_proquest_miscellaneous_2501266662 |
source | Springer Nature |
subjects | a1-antitrypsin Albumin Central nervous system Central nervous system diseases Child, Preschool Colitis Complications and side effects Dialysis Escherichia coli infections Health aspects Hematocrit Hemodialysis Hemolytic uremic syndrome Hemolytic-Uremic Syndrome - complications Hemolytic-Uremic Syndrome - epidemiology Hemorrhage Humans Hypoalbuminemia - complications Hypoalbuminemia - epidemiology Hyponatremia Leukocytes Medicine Medicine & Public Health Nephrology Original Article Pediatrics Regression analysis Renal Dialysis Risk Factors Shiga-Toxigenic Escherichia coli Urology |
title | Hypoalbuminemia: a risk factor in patients with STEC-associated hemolytic uremic syndrome |
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