Impact of radial margins after esophagectomy for esophageal cancer

The prognostic significance of radial margin (RM) involvement in esophagectomy cancer specimens is unclear. Our study investigated survival and recurrence rates between different depths of RM involvement. We retrospectively analyzed 1103 esophagectomies at our institution from 2005 to 2019. Patients...

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Bibliographic Details
Published in:European journal of surgical oncology 2021-09, Vol.47 (9), p.2313-2322
Main Authors: Bravo-Iñiguez, Carlos E., He, Zhicheng, Dezube, Aaron R., Mazzola, Emanuele, Yelamanchili, Nitya, Zhao, Lei, Bueno, Raphael, Swanson, Scott J., White, Abby, Wiener, Daniel C., Jaklitsch, Michael T., Wee, Jon O.
Format: Article
Language:English
Subjects:
Aged
Distant recurrence
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophageal Neoplasms - therapy
Esophagectomy
Esophagectomy - adverse effects
Female
Humans
Kaplan-Meier Estimate
Loco-regional recurrence
Lymphatic Metastasis
Male
Margins of Excision
Middle Aged
Neoadjuvant Therapy
Neoplasm Recurrence, Local
Neoplasm, Residual
Postoperative Complications - etiology
Proportional Hazards Models
Radial margins
Retrospective Studies
Risk Factors
Survival
Survival Rate
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Summary:The prognostic significance of radial margin (RM) involvement in esophagectomy cancer specimens is unclear. Our study investigated survival and recurrence rates between different depths of RM involvement. We retrospectively analyzed 1103 esophagectomies at our institution from 2005 to 2019. Patients were grouped by three-tier stratification: negative RM > 1 mm away, direct RM involvement at 0 mm, and close RM between 0 mm and 1 mm. Survival, loco-regional and distant recurrences were analyzed. 1103 esophageal cancer patients were analyzed. 389 patients had recurrence (35.3%). Median survival (13.2 months) and recurrence rates (71%) were worst with direct RM (p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2021.02.014